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Articles in Press
7/4/2025 8:50:07 AM | Browse: 23 | Download: 0
Category |
Oncology |
Manuscript Type |
Minireviews |
Article Title |
Challenges and proposed solutions to the adoption of cell free DNA in screening, detecting and prognosticating colorectal cancer
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Megan Wern-Ee Chua and Dedrick Kok-Hong Chan |
Funding Agency and Grant Number |
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Corresponding Author |
Dedrick Kok-Hong Chan, Department of Colorectal Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore. surckhd@nus.edu.sg |
Key Words |
Cell free DNA; Circulating tumour deoxyribonucleic acid; Colorectal cancer; Liquid biopsy; Screening; Detection; Prognostication |
Core Tip |
Cell free DNA (cfDNA) carries information about colorectal cancer-specific genetic and epigenetic alterations which can aid in screening, detection and prognostication. Detection of genetic alterations is made difficult by low signal-to-noise ratio owing to an abundance of background non-tumorigenic mutations. Low amounts of cfDNA in healthy individuals negatively affects the sequencing performance and limit of detection of assays making screening non-feasible. One solution is to harvest cfDNA from peritoneal fluid or stool as this is more representative of the primary tumour compared to plasma-derived cfDNA. Alternatively, increasing the sensitivity of sequencing technologies would allow for the detection of low frequency mutations. |
Citation |
Chua MWE, Chan DKH. Challenges and proposed solutions to the adoption of cell free DNA in screening, detecting and prognosticating colorectal cancer. World J Gastrointest Oncol 2025; In press |
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Received |
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2025-03-04 05:17 |
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Peer-Review Started |
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2025-03-04 05:17 |
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To Make the First Decision |
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Return for Revision |
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2025-04-08 09:41 |
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Revised |
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2025-04-08 16:14 |
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Second Decision |
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2025-07-04 02:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-04 08:50 |
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Articles in Press |
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2025-07-04 08:50 |
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Publication Fee Transferred |
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2025-04-13 07:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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ISSN |
1948-5204 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
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