Publication Name	World Journal of Gastroenterology
Manuscript ID	106670
Country	Romania

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Personalized surveillance in colorectal cancer: Integrating circulating tumor DNA and artificial intelligence into post-treatment follow-up
Manuscript Source	Invited Manuscript
All Author List	Ionut Negoi
Funding Agency and Grant Number
Corresponding Author	Ionut Negoi, Associate Professor, Head, MD, PhD, Department of General Surgery, Carol Davila University of Medicine and Pharmacy Bucharest, Clinical Emergency Hospital of Bucharest, No 8 Floreasca Street, Sector 1, Bucharest 014461, Romania. negoiionut@gmail.com
Key Words	Colorectal cancer; Post-treatment surveillance; Tumor recurrence; Follow-up protocols; Circulating tumor DNA; Artificial intelligence
Core Tip	Given the increasing incidence of colorectal cancer, especially among younger populations, effective post-treatment surveillance is essential for early detection of recurrence and improved outcomes. Intensive surveillance has variable efficacy, underscoring the need for personalized, risk-based protocols. Suboptimal adherence to guidelines further highlights the need for efficient, individualized approaches. Circulating tumor DNA shows promise as a biomarker, offering high specificity (0.95, 95%CI: 0.91–0.97) and diagnostic accuracy (odds ratio 37.6, 95%CI: 20.8–68.0). Additionally, artificial intelligence models utilizing patient and tumor data have potential to refine surveillance, with predictive accuracy ranging from 0.581 to 0.979. Nonetheless, cost, accessibility, and validation remain significant barriers to widespread clinical implementation.
Citation	<p>Negoi I. Personalized surveillance in colorectal cancer: Integrating circulating tumor DNA and artificial intelligence into post-treatment follow-up. <i>World J Gastroenterol</i> 2025; 31(18): 106670</p>

Received	2025-03-04 08:35
Peer-Review Started	2025-03-04 08:35
To Make the First Decision
Return for Revision	2025-03-28 01:59
Revised	2025-04-07 01:25
Second Decision	2025-04-18 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-18 03:41
Articles in Press	2025-04-18 03:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-04-23 16:46
Typeset the Manuscript	2025-05-07 00:33

ISSN	1007-9327 (print) and 2219-2840 (online)
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