Publication Name	World Journal of Hepatology
Manuscript ID	106675
Country	Australia

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Liver stiffness measurements in patients with metabolic dysfunction-associated steatotic liver disease: Updates on the method effectiveness and perspectives
Manuscript Source	Invited Manuscript
All Author List	Olga Sukocheva, Tsai-Wing Ow, Damian Harding, Marc Le Mire and Edmund Tse
Funding Agency and Grant Number
Corresponding Author	Olga Sukocheva, Senior Scientist, Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Central Adelaide Local Health Network, Port Road, Adelaide 5000, South Australia, Australia. olga.sukocheva@sa.gov.au
Key Words	Non-alcoholic fatty liver disease; Liver fibrosis; Metabolic syndrome; Metabolic dysfunction-associated steatotic liver disease; Liver stiffness measurement; Transient elastography
Core Tip	Clinical diagnostics of metabolic dysfunction-associated steatotic liver disease (MASLD) relies on non-invasive diagnostic tools, such as transient elastography (TE)/FibroScan®. TE measures liver stiffness, an important clinical marker of liver fibrosis and cirrhosis. However, TE measurements have limited accuracy in obese patients. This study reviews the limitations of TE-based diagnostics and discusses the combined scoring algorithm. Data review indicates that in patients with MASLD reliable diagnostic accuracy can be achieved by combining FibroScan® measurements with various blood test-based scores, including agile and fibrosis score indicators.
Citation	Sukocheva O, Ow TW, Harding D, Le Mire M, Tse E. Liver stiffness measurements in patients with metabolic dysfunction-associated steatotic liver disease: Updates on the method effectiveness and perspectives. World J Hepatol 2025; In press

Received	2025-03-04 12:35
Peer-Review Started	2025-03-07 01:36
To Make the First Decision
Return for Revision	2025-04-09 12:49
Revised	2025-05-01 00:35
Second Decision	2025-06-25 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-25 08:43
Articles in Press	2025-06-25 08:43
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ISSN	1948-5182 (online)
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