Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	106723
Country	China

Category	Immunology
Manuscript Type	Minireviews
Article Title	Adoptive cell therapy in colorectal cancer: Focus on chimeric antigen receptor T cells
Manuscript Source	Invited Manuscript
All Author List	Meng-Yan Chen, Chen Wang, Yu-Gang Wang and Min Shi
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of the Science and Technology Commission of Shanghai Municipality, China No. 23ZR1458300 Key Discipline Project of Shanghai Municipal Health System, China No. 2024ZDXK0004 Doctoral Innovation Talent Base Project for Diagnosis and Treatment of Chronic Liver Diseases, China No. RCJD2021B02 Pujiang Project of Shanghai Magnolia Talent Plan, China No. 24PJD098
Corresponding Author	Min Shi, Chief Physician, MD, Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Changning District, Shanghai 200336, China. sm1790@shtrhospital.com
Key Words	Colorectal cancer; Adoptive cell therapy; Immunotherapy; Chimeric antigen receptor T cells; Tumor-infiltrating lymphocytes; T-cell receptor-engineered T cells
Core Tip	This review discusses adoptive cell therapy approaches for colorectal cancer (CRC), emphasizing chimeric antigen receptor (CAR) T cell therapy. Despite its success in hematological malignancies, CAR-T therapy faces challenges in solid tumors like CRC, including antigen heterogeneity, tumor microenvironment immunosuppression, and on-target off-tumor toxicity. The review explores combinatorial strategies, such as immune checkpoint inhibitors and clustered regularly interspaced short palindromic repeats/Cas9 gene editing, to overcome these challenges and enhance CAR-T cell specificity, resistance to immunosuppressive signals, and in vivo functionality.
Citation	Chen MY, Wang C, Wang YG, Shi M. Adoptive cell therapy in colorectal cancer: Focus on chimeric antigen receptor T cells. World J Gastrointest Oncol 2025; In press

Received	2025-03-06 09:04
Peer-Review Started	2025-03-06 09:04
To Make the First Decision
Return for Revision	2025-03-26 11:19
Revised	2025-04-07 10:27
Second Decision	2025-05-29 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-29 07:04
Articles in Press	2025-05-29 07:04
Publication Fee Transferred
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Typeset the Manuscript

ISSN	1948-5204 (online)
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