Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	106724
Country	Türkiye

Category	Oncology
Manuscript Type	Minireviews
Article Title	Predicting neoadjuvant chemoradiotherapy response in rectal cancer: Insights from biomarkers to clinical practice
Manuscript Source	Invited Manuscript
All Author List	Hikmet Pehlevan-Özel, Eda Şahingöz, Mert Altaş and Mesut Tez
Funding Agency and Grant Number
Corresponding Author	Mesut Tez, Professor, Department of Surgery, University of Health Sciences, Ankara City Hospital, No. 1 Bilkent Street, District of Universities, Ankara 06800, Türkiye. mesuttez@yahoo.com
Key Words	Rectal cancer; Neoadjuvant chemoradiotherapy; Pathological complete response; Biomarkers; Tumor regression grading; Clinical predictors; Radiomics
Core Tip	This review synthesizes biomarkers predicting neoadjuvant chemoradiotherapy response in rectal cancer, including clinical predictors (e.g., tumor size, nodal status), histopathological features (e.g., tumor regression grading), molecular markers (e.g., KRAS mutations), microenvironmental factors (e.g., tumor-infiltrating lymphocytes), and radiomics, to guide personalized treatment and improve outcomes.
Citation	Pehlevan-Özel H, Şahingöz E, Altaş M, Tez M. Predicting neoadjuvant chemoradiotherapy response in rectal cancer: Insights from biomarkers to clinical practice. World J Gastrointest Surg 2025; In press

Received	2025-03-06 10:09
Peer-Review Started	2025-03-06 10:09
To Make the First Decision
Return for Revision	2025-03-31 09:03
Revised	2025-03-31 19:52
Second Decision	2025-05-19 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-19 07:59
Articles in Press	2025-05-19 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-05-23 02:36
Typeset the Manuscript

ISSN	1948-9366 (online)
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