Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	106781
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	GEN1 regulates cell proliferation, migration, apoptosis and ferroptosis in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Qi Zhang, Zu-Guo Yuan, Kai-Feng Zheng and Ke Chen
Funding Agency and Grant Number
Corresponding Author	Qi Zhang, Department of Gastroenterology, The Affiliated People’s Hospital of Ningbo University, No. 251 Baizhang East Road, Ningbo 315000, Zhejiang Province, China. matin219@163.com
Key Words	Gastric cancer; GEN1; Cell cycle; Ferroptosis; The Cancer Genome Atlas database
Core Tip	GEN1 promotes gastric cancer (GC) cell proliferation and migration while suppressing apoptosis and ferroptosis. Targeting GEN1 not only disrupts mitochondrial function and cell cycle progression but also sensitizes GC cells to ferroptosis and chemotherapy. These findings highlight GEN1 as a potential therapeutic target for enhancing treatment efficacy in GC.
Citation	Zhang Q, Yuan ZG, Zheng KF, Chen K. GEN1 regulates cell proliferation, migration, apoptosis and ferroptosis in gastric cancer. World J Gastrointest Oncol 2025; In press

Received	2025-04-08 11:09
Peer-Review Started	2025-04-08 11:09
To Make the First Decision
Return for Revision	2025-04-30 07:19
Revised	2025-05-08 04:09
Second Decision	2025-06-20 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-20 07:24
Articles in Press	2025-06-20 07:24
Publication Fee Transferred	2025-05-13 00:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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