Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	106801
Country	United States

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Postoperative immune checkpoint inhibitors plus anti-angiogenesis for hepatitis B virus-associated hepatocellular carcinoma: Analyzing the evidence and future prospects
Manuscript Source	Invited Manuscript
All Author List	Arunkumar Krishnan and Diptasree Mukherjee
Funding Agency and Grant Number
Corresponding Author	Arunkumar Krishnan, MD, Department of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com
Key Words	Adverse events; Biomarkers; Bias; Confounders; Hepatitis B virus; Hepatocellular carcinoma; Postoperative combined therapy; Immunotherapy; Follow-up
Core Tip	A recent study by Lu et al examined postoperative combined therapy (PCT) for hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC). While the findings provide important insights, it is essential to acknowledge several significant limitations. These include the potential for selection bias, a small sample size, and an insufficient focus on monitoring hepatitis B virus reactivation in detail. Future research should prioritize prospective, randomized controlled trials and adopt biomarker-driven approaches to advance the knowledge of the efficacy and safety of PCT. Moreover, extending follow-up periods and fostering global collaboration could enhance treatment outcomes and more effective patient care strategies in managing HBV-HCC.
Citation	Krishnan A, Mukherjee D. Postoperative immune checkpoint inhibitors plus anti-angiogenesis for hepatitis B virus-associated hepatocellular carcinoma: Analyzing the evidence and future prospects. World J Gastrointest Oncol 2025; In press

Received	2025-03-07 10:07
Peer-Review Started	2025-03-07 10:08
To Make the First Decision
Return for Revision	2025-04-02 10:53
Revised	2025-04-09 14:26
Second Decision	2025-04-18 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-18 06:45
Articles in Press	2025-04-18 06:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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