Publication Name	World Journal of Diabetes
Manuscript ID	106884
Country	China

Category	Pediatrics
Manuscript Type	Letter to the Editor
Article Title	Immune biomarkers as early indicators of renal damage in type 1 diabetic children: A step toward translational medicine
Manuscript Source	Invited Manuscript
All Author List	Jian-Wen Fan, Su-Yi Xu, Jun Wu and Yong-Wei Yu
Funding Agency and Grant Number
Corresponding Author	Yong-Wei Yu, Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. yuyongwei@zju.edu.cn
Key Words	Type 1 diabetes; Immune biomarkers; Renal damage; Risk stratification; Translational medicine
Core Tip	Immune biomarkers play a crucial role in the early detection of renal damage in children with type 1 diabetes. This letter highlights the need for integrating immune indicators into a dynamic risk stratification model, combining metabolic and genetic factors for improved predictive accuracy. Additionally, we emphasize the importance of longitudinal studies to assess biomarker temporal dynamics and explore immunomodulatory strategies for early intervention. Advancing these approaches could enhance the clinical utility of immune biomarkers, facilitating their translation into routine diagnostics and personalized treatment strategies for diabetic nephropathy prevention.
Citation	Fan JW, Xu SY, Wu J, Yu YW. Immune biomarkers as early indicators of renal damage in type 1 diabetic children: A step toward translational medicine. World J Diabetes 2025; In press

Received	2025-03-10 09:12
Peer-Review Started	2025-03-11 07:48
To Make the First Decision
Return for Revision	2025-03-27 09:26
Revised	2025-04-04 15:45
Second Decision	2025-04-14 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-14 06:38
Articles in Press	2025-04-14 06:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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