Publication Name	World Journal of Cardiology
Manuscript ID	106885
Country	Russia

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Comparative characteristics of in vitro models for studying angiogenesis in cardiovascular disease
Manuscript Source	Invited Manuscript
All Author List	Anastasia Kalinina, Nina Mzhavanadze, Roman Kalinin and Igor Suchkov
Funding Agency and Grant Number
Corresponding Author	Nina Mzhavanadze, Department of cardiovascular, endovascular surgery and diagnostic radiology, Ryazan State Medical University, Vysokovoltnaya, 9, Ryazan 390026, Russia. nina_mzhavanadze@mail.ru
Key Words	Angiogenesis; In vitro models; Cell technologies; Cell cultures; Endothelial cells
Core Tip	Experimental angiogenesis research is rapidly evolving in cardiovascular medicine. In vitro models offer precise control and stable experimental conditions with favorable cost-effectiveness compared with ex vivo and in vivo approaches. Limitations include incomplete reproduction of physiological conditions, particularly in 2D systems. Wider implementation of 3D culture, microfluidic platforms, and artificial intelligence should be considered to achieve more comprehensive and physiologically relevant studies of angiogenesis despite greater complexity and cost.
Citation	Kalinina A, Mzhavanadze N, Kalinin R, Suchkov I. Comparative characteristics of in vitro models for studying angiogenesis in cardiovascular disease. World J Cardiol 2025; In press

Received	2025-03-10 05:50
Peer-Review Started	2025-03-10 05:51
To Make the First Decision
Return for Revision	2025-05-17 08:45
Revised	2025-05-30 08:26
Second Decision	2025-11-25 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-25 12:46
Articles in Press	2025-11-25 12:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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