Publication Name	World Journal of Stem Cells
Manuscript ID	106902
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Editorial
Article Title	Mesenchymal stem cell‐derived exosomes and Wnt/β-catenin pathway: Unifying mechanisms of multi-organ regeneration and the path to precision clinical translation
Manuscript Source	Invited Manuscript
All Author List	Xiong Yan, Ya-Xiong Guo, Yu-Xiang Liu and Chun Liu
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Research Project of Basic Research Program in Shanxi Province 202203021221268 National Natural Science Foundation of China 82305030
Corresponding Author	Chun Liu, Chief Physician, Consultant, Dean, Professor, The First Clinical Medical School, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan 030001, Shanxi Province, China. sxtyliuchun@126.com
Key Words	Mesenchymal stem cell; Wnt/β-catenin pathway; Exosomes; Clinical translation; Regenerative medicine
Core Tip	Mesenchymal stem cell-derived exosomes represent a novel form of cell-free therapy that operates through the activation of the Wnt/β-catenin pathway using the substances they contain, including proteins, microRNAs, and growth factors. These exosomes can stimulate cell proliferation, elicit anti-inflammatory responses, and promote the repair of multiple organs and tissues. However, the translation of these findings into clinical practice remains challenging. This is due to the need for standardization in exosome production and purification and the development of effective administration and storage methods. Additionally, concerns regarding immunogenicity and tumorigenicity further complicate the translation of exosome therapy into clinical practice. Therefore, further exploration is necessary to fully assess the potential of exosome therapy as a personalized regenerative medicine approach.
Citation	Yan X, Guo YX, Liu YX, Liu C. Mesenchymal stem cell‐derived exosomes and Wnt/β-catenin pathway: Unifying mechanisms of multi-organ regeneration and the path to precision clinical translation. World J Stem Cells 2025; In press

Received	2025-03-11 10:19
Peer-Review Started	2025-03-12 00:45
To Make the First Decision
Return for Revision	2025-03-21 07:50
Revised	2025-03-31 03:00
Second Decision	2025-05-08 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-08 08:07
Articles in Press	2025-05-08 08:07
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-05-13 20:18
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com