Publication Name	World Journal of Clinical Oncology
Manuscript ID	106981
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	New advances in oral microbiology and tumor research
Manuscript Source	Invited Manuscript
All Author List	Hong-Jun Liang, Xian-Yi Tan, Di Li, Cheng Lin, Suo-Yi Huang, Guo-Chao Nie, Xue-Feng Guo, Zheng-Bao Zhang, Xiao-Nian Zhu and Sheng-Kui Tan
Funding Agency and Grant Number	Funding Agency Grant Number Key Science and Technology Research and Development Program Project of Guangxi GuikeAB22035017 Key Science and Technology Research and Development Program Project of Guangxi GuikeAB25069071
Corresponding Author	Xiao-Nian Zhu, MD, Professor, Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, Zhiyuan Road 1, Guilin 541199, Guangxi Zhuang Autonomous Region, China. zhuxiaonian0403@163.com
Key Words	Oral microbiota; Tumorigenesis; Cancer; Microbial dysbiosis; Multi-omics integration; Precision medicine
Core Tip	This review synthesizes recent progress in understanding the complex interactions between the oral microbiota and various cancers, particularly oral squamous cell carcinoma, esophageal adenocarcinoma, and pancreatic ductal adenocarcinoma. It highlights the roles of pathogenic bacteria such as Porphyromonas gingivalis and Fusobacterium nucleatum in promoting tumor progression through chronic inflammation, metabolic toxin production, and immune evasion. The review also explores innovative therapeutic strategies, including probiotics, oral microbiota transplantation, and CRISPR-based bacterial editing, while emphasizing the potential of saliva-based microbial biomarkers for non-invasive cancer screening. This work aims to translate microbial-related research into clinical applications, with the goal of mitigating the global cancer burden through early diagnosis and microbiome-targeted therapy.
Citation	Liang HJ, Tan XY, Li D, Lin C, Huang SY, Nie GC, Guo XF, Zhang ZB, Zhu XN, Tan SK. New advances in oral microbiology and tumor research. World J Clin Oncol 2025; In press

Received	2025-03-13 08:41
Peer-Review Started	2025-03-13 08:41
To Make the First Decision
Return for Revision	2025-04-04 01:30
Revised	2025-04-14 19:02
Second Decision	2025-06-05 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-05 08:53
Articles in Press	2025-06-05 08:53
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ISSN	2218-4333 (online)
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