Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	107021
Country	Türkiye

Category	Pathology
Manuscript Type	Retrospective Cohort Study
Article Title	Evaluation of tumor budding, desmoplastic reaction, and lymphocytic infiltration in predicting survival for pancreatic ductal adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Anıl Alpsoy, Aysen Yavuz, Kubra Simsek, Busra Altunay, Mustafa Karaca, Betul Unal, Cumhur I Bassorgun, Ali M Tatli and Gulsum O Elpek
Funding Agency and Grant Number
Corresponding Author	Gulsum O Elpek, MD, Professor, Department of Pathology, Akdeniz University, School of Medicine, Dumlupinar Bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr
Key Words	Pancreatic ductal adenocarcinoma; Tumor microenvironment; Tumor budding; Desmoplastic reaction; Tumor-infiltrating lymphocytes; Prognostic factors
Core Tip	Pancreatic ductal adenocarcinoma is a highly aggressive malignancy, necessitating novel histopathological markers for better prognostic stratification. This study evaluated tumor budding, desmoplastic reaction, and tumor-infiltrating lymphocytes in patients with pancreatic ductal adenocarcinoma. Peritumoral budding (PTB) correlated with tumor size, while intratumoral budding (ITB) was linked to lymph node involvement. Both PTB and ITB were independent prognostic factors for poor survival. Additionally, high PTB and ITB levels were associated with immature stroma, suggesting a role in epithelial-mesenchymal transition. These findings highlighted the prognostic value of tumor budding and its potential integration into pathology reporting protocols.
Citation	Alpsoy A, Yavuz A, Simsek K, Altunay B, Karaca M, Unal B, Bassorgun CI, Tatli AM, Elpek GO. Evaluation of tumor budding, desmoplastic reaction, and lymphocytic infiltration in predicting survival for pancreatic ductal adenocarcinoma. World J Gastrointest Oncol 2025; In press

Received	2025-03-14 07:52
Peer-Review Started	2025-03-14 07:52
To Make the First Decision
Return for Revision	2025-04-01 12:36
Revised	2025-04-15 11:22
Second Decision	2025-05-19 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-19 08:44
Articles in Press	2025-05-19 08:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-31 17:43

ISSN	1948-5204 (online)
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