| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Molecular mechanisms of thymopoietin in papillary thyroid cancer: Multiplatform gene expression data, gene knockout screening, and in-house immunohistochemistry
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chang Song, Yu-Yan Pang, Shang-Yi Lu, Bin Li, Dong-Ming Li, Rong-Quan He, Di-Yuan Qin, Shi-De Li, Ning Qv, Yan-Mei Chen, Gang Chen, Juan He and Xiao-Bo Jiang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project |
No. Z-A20220521 |
| Guangxi Higher Education Undergraduate Teaching Reform Project |
No. 2022JGA147 |
| The National College Students’ Innovation and Entrepreneurship Training Program |
No. 202310598042 |
|
| Corresponding Author |
Xiao-Bo Jiang, Associate Chief Physician, Academic Affairs Department, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. jiang_xiaobo_gx@163.com |
| Key Words |
Thymopoietin; Papillary thyroid carcinoma; Immunohistochemistry; Molecular mechanisms; Clustered regularly interspaced short palindromic repeats Screening; Cancer Cell Line Encyclopedia |
| Core Tip |
This study provides the first comprehensive analysis of thymopoietin (TMPO) in papillary thyroid cancer using global high-throughput sequencing datasets and multilevel analyses. This reveals that TMPO is significantly overexpressed in papillary thyroid cancer cells, with potential roles in promoting tumor proliferation, invasiveness, and immune interactions. Its inhibition via clustered regularly interspaced short palindromic repeats knockout significantly reduces cell proliferation, highlighting its potential as a therapeutic target. |
| Citation |
Song C, Pang YY, Lu SY, Li B, Li DM, He RQ, Qin DY, Li SD, Qv N, Chen YM, Chen G, He J, Jiang XB. Molecular mechanisms of thymopoietin in papillary thyroid cancer: Multiplatform gene expression data, gene knockout screening, and in-house immunohistochemistry. World J Clin Oncol 2025; In press |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
