Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	107110
Country	Malaysia

Category	Surgery
Manuscript Type	Systematic Reviews
Article Title	Multi-omics perspectives for gastrointestinal malignancy: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Thai-Hau Koo, Yi-Lin Lee, Xue-Bin Leong, Firdaus Hayati, Mohd Hazeman Zakaria and Andee Dzulkarnaen Zakaria
Funding Agency and Grant Number
Corresponding Author	Andee Dzulkarnaen Zakaria, MD, Professor, Department of Surgery, School of Medical Sciences, University Sains Malaysia, Jalan Raja Perempuan Zainab 2, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia. andee@usm.my
Key Words	Proteomic; Multi-omics; Gastrointestinal malignancy; Precision oncology; Biomarker discovery; Therapeutic resistance
Core Tip	Gastrointestinal malignancies present substantial diagnostic and therapeutic challenges due to their molecular complexity. This systematic review highlights how comprehensive omics strategies incorporating genomic, transcriptomic, proteomic, and metabolomic data and epigenomics, integrated with machine learning and artificial intelligence, can revolutionize precision oncology. These strategies enable early detection through biomarkers like circulating tumor DNA and extracellular vesicles, enhance risk stratification, and uncover mechanisms of drug resistance and tumor heterogeneity, paving the way for individualized gastrointestinal cancer therapies.
Citation	Koo TH, Lee YL, Leong XB, Hayati F, Zakaria MH, Zakaria AD. Multi-omics perspectives for gastrointestinal malignancy: A systematic review. World J Gastrointest Surg 2025; In press

Received	2025-03-17 04:04
Peer-Review Started	2025-03-17 04:04
To Make the First Decision
Return for Revision	2025-04-14 10:36
Revised	2025-04-24 22:30
Second Decision	2025-05-28 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-28 08:59
Articles in Press	2025-05-28 08:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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