Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	107121
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	MicroRNA 195, lactate dehydrogenase 5, phosphatase and tensin homologue in colorectal cancer: Clinicopathology and prognosis
Manuscript Source	Unsolicited Manuscript
All Author List	Zuo Tang and Li-Ming Wen
Funding Agency and Grant Number
Corresponding Author	Li-Ming Wen, Chief Physician, Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 319 Section 3, Zhongshan Road, Luzhou 646000, Sichuan Province, China. wenlm404@yeah.net
Key Words	Colorectal cancer; MicroRNA 195; Lactate dehydrogenase-5; Phosphatase and tensin homologue; Clinicopathology; Prognosis
Core Tip	Colorectal cancer (CRC) incidence has shown a sustained annual increase with a notable trend toward younger-onset cases, significantly affecting public health. In this retrospective cohort study, we systematically conducted clinical data of 53 CRC patients, performing quantitative comparison of microRNA 195 (miR195), lactate dehydrogenase-5 (LDH-5), and phosphatase and tensin homologue (PTEN) expression profiles between tumor tissues and matched adjacent normal tissues, as well as their correlation with clinicopathological parameters and prognosis. Our findings revealed that reduced miR195 and PTEN expression, coupled high LDH-5 expression exhibited strong mechanistic associations with CRC pathogenesis and disease progression, suggesting that molecular alterations as potential utility as a novel diagnostic indicators for precision oncology applications.
Citation	Tang Z, Wen LM. MicroRNA 195, lactate dehydrogenase 5, phosphatase and tensin homologue in colorectal cancer: Clinicopathology and prognosis. World J Gastrointest Surg 2025; In press

Received	2025-03-21 09:47
Peer-Review Started	2025-03-21 09:47
To Make the First Decision
Return for Revision	2025-04-08 12:37
Revised	2025-04-20 10:57
Second Decision	2025-05-28 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-28 09:26
Articles in Press	2025-05-28 09:26
Publication Fee Transferred	2025-04-24 06:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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