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Articles in Press
7/4/2025 10:23:39 AM | Browse: 30 | Download: 0
Category |
Cell & Tissue Engineering |
Manuscript Type |
Basic Study |
Article Title |
Aligned nanofiber scaffolds combined with cyclic stretch facilitate mesenchymal stem cell differentiation for ligament engineering
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Cheng-Wei Yang, Ya-Qiang Zhang, Hong Chang, Rui Gao, Dan Chen and Hao Yao |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Sichuan Province Science and Technology Support Program |
2024NSFSC1292 |
Program of General Hospital of Western Theater Command |
2021-XZYG-C45, 2021-XZYG-B32 |
Natural Science Foundation of Gansu Province |
23JRRA538 |
National Natural Science Foundation of China |
81601905 |
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Corresponding Author |
Hao Yao, PhD, Department of Hematology, The General Hospital of Western Theater Command PLA, No. 270 Rongdu Avenue, Jinniu District, Chengdu 610083, Sichuan Province, China. yaohao9001@163.com |
Key Words |
Tendon tissue engineering; Bone marrow-derived mesenchymal stem cells; Nanofiber scaffold; Cyclic tensile strain; Tenogenic differentiation; Ras homolog gene family (Rho)-associated coiled coil-containing kinase inhibition; Y27632 |
Core Tip |
This study investigated the role of aligned nanofiber scaffolds and cyclic stretch in promoting Bone marrow-derived mesenchymal stem cell (BMSC) differentiation towards ligamentous tissue. We demonstrate that cyclic tensile strain, when applied to BMSCs on aligned nanofiber scaffolds, enhances tenogenic differentiation, as demonstrated by increased expression of collagen and tenogenic markers. These findings suggest that mechanical cues and scaffold alignment are critical in guiding BMSC differentiation for ligament tissue engineering, providing valuable insights for developing strategies to improve ligament regeneration. |
Citation |
Yang CW, Zhang YQ, Chang H, Gao R, Chen D, Yao H. Aligned nanofiber scaffolds combined with cyclic stretch facilitate mesenchymal stem cell differentiation for ligament engineering. World J Stem Cells 2025; In press |
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Received |
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2025-03-25 04:56 |
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Peer-Review Started |
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2025-03-25 04:57 |
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To Make the First Decision |
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Return for Revision |
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2025-04-28 09:15 |
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Revised |
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2025-05-11 14:09 |
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Second Decision |
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2025-06-27 06:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-04 10:23 |
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Articles in Press |
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2025-07-04 10:23 |
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Publication Fee Transferred |
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2025-05-13 13:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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ISSN |
1948-0210 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
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