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7/4/2025 10:23:39 AM | Browse: 30 | Download: 0
Publication Name World Journal of Stem Cells
Manuscript ID 107124
Country China
Category Cell & Tissue Engineering
Manuscript Type Basic Study
Article Title Aligned nanofiber scaffolds combined with cyclic stretch facilitate mesenchymal stem cell differentiation for ligament engineering
Manuscript Source Unsolicited Manuscript
All Author List Cheng-Wei Yang, Ya-Qiang Zhang, Hong Chang, Rui Gao, Dan Chen and Hao Yao
Funding Agency and Grant Number
Funding Agency Grant Number
Sichuan Province Science and Technology Support Program 2024NSFSC1292
Program of General Hospital of Western Theater Command 2021-XZYG-C45, 2021-XZYG-B32
Natural Science Foundation of Gansu Province 23JRRA538
National Natural Science Foundation of China 81601905
Corresponding Author Hao Yao, PhD, Department of Hematology, The General Hospital of Western Theater Command PLA, No. 270 Rongdu Avenue, Jinniu District, Chengdu 610083, Sichuan Province, China. yaohao9001@163.com
Key Words Tendon tissue engineering; Bone marrow-derived mesenchymal stem cells; Nanofiber scaffold; Cyclic tensile strain; Tenogenic differentiation; Ras homolog gene family (Rho)-associated coiled coil-containing kinase inhibition; Y27632
Core Tip This study investigated the role of aligned nanofiber scaffolds and cyclic stretch in promoting Bone marrow-derived mesenchymal stem cell (BMSC) differentiation towards ligamentous tissue. We demonstrate that cyclic tensile strain, when applied to BMSCs on aligned nanofiber scaffolds, enhances tenogenic differentiation, as demonstrated by increased expression of collagen and tenogenic markers. These findings suggest that mechanical cues and scaffold alignment are critical in guiding BMSC differentiation for ligament tissue engineering, providing valuable insights for developing strategies to improve ligament regeneration.
Citation Yang CW, Zhang YQ, Chang H, Gao R, Chen D, Yao H. Aligned nanofiber scaffolds combined with cyclic stretch facilitate mesenchymal stem cell differentiation for ligament engineering. World J Stem Cells 2025; In press
Received
2025-03-25 04:56
Peer-Review Started
2025-03-25 04:57
To Make the First Decision
Return for Revision
2025-04-28 09:15
Revised
2025-05-11 14:09
Second Decision
2025-06-27 06:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-04 10:23
Articles in Press
2025-07-04 10:23
Publication Fee Transferred
2025-05-13 13:37
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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