Publication Name	World Journal of Stem Cells
Manuscript ID	107124
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Aligned nanofiber scaffolds combined with cyclic stretch facilitate mesenchymal stem cell differentiation for ligament engineering
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng-Wei Yang, Ya-Qiang Zhang, Hong Chang, Rui Gao, Dan Chen and Hao Yao
Funding Agency and Grant Number	Funding Agency Grant Number Sichuan Province Science and Technology Support Program 2024NSFSC1292 Program of General Hospital of Western Theater Command 2021-XZYG-C45, 2021-XZYG-B32 Natural Science Foundation of Gansu Province 23JRRA538 National Natural Science Foundation of China 81601905
Corresponding Author	Hao Yao, PhD, Department of Hematology, The General Hospital of Western Theater Command PLA, No. 270 Rongdu Avenue, Jinniu District, Chengdu 610083, Sichuan Province, China. yaohao9001@163.com
Key Words	Tendon tissue engineering; Bone marrow-derived mesenchymal stem cells; Nanofiber scaffold; Cyclic tensile strain; Tenogenic differentiation; Ras homolog gene family (Rho)-associated coiled coil-containing kinase inhibition; Y27632
Core Tip	This study investigated the role of aligned nanofiber scaffolds and cyclic stretch in promoting Bone marrow-derived mesenchymal stem cell (BMSC) differentiation towards ligamentous tissue. We demonstrate that cyclic tensile strain, when applied to BMSCs on aligned nanofiber scaffolds, enhances tenogenic differentiation, as demonstrated by increased expression of collagen and tenogenic markers. These findings suggest that mechanical cues and scaffold alignment are critical in guiding BMSC differentiation for ligament tissue engineering, providing valuable insights for developing strategies to improve ligament regeneration.
Citation	Yang CW, Zhang YQ, Chang H, Gao R, Chen D, Yao H. Aligned nanofiber scaffolds combined with cyclic stretch facilitate mesenchymal stem cell differentiation for ligament engineering. World J Stem Cells 2025; In press

Received	2025-03-25 04:56
Peer-Review Started	2025-03-25 04:57
To Make the First Decision
Return for Revision	2025-04-28 09:15
Revised	2025-05-11 14:09
Second Decision	2025-06-27 06:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-04 10:23
Articles in Press	2025-07-04 10:23
Publication Fee Transferred	2025-05-13 13:37
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Typeset the Manuscript

ISSN	1948-0210 (online)
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