Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	107148
Country	Türkiye

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Glucagon-like peptide-1 receptor agonists: Evolution, gastrointestinal adverse effects, and future directions
Manuscript Source	Invited Manuscript
All Author List	Alaa Ismail, Mohab Sherif Amer and Ahmed Tawheed
Funding Agency and Grant Number
Corresponding Author	Ahmed Tawheed, Consultant, Department of Gastroenterology, Firat University, Firat Campus, Elazig 23119, Türkiye. atawheed1990@gmail.com
Key Words	Glucagon-like peptide-1 receptor agonists; Obesity; Gastrointestinal; Adverse events; Diabetes
Core Tip	Obesity is a global pandemic causing chronic diseases like type 2 diabetes mellitus (T2DM) and cardiovascular disease. Lifestyle modifications and bariatric surgeries are the primary management methods. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a rising star for managing T2DM by controlling blood sugar and weight loss. However, they have side effects like nausea, vomiting, diarrhea, and gastrointestinal (GI) adverse events. More serious risks include pancreatitis, gallbladder diseases, and thyroid C-cell cancers. This review discusses GLP-1RAs' role in obesity management and GI safety considerations.
Citation	Ismail A, Amer MS, Tawheed A. Glucagon-like peptide-1 receptor agonists: Evolution, gastrointestinal adverse effects, and future directions. World J Gastrointest Pharmacol Ther 2025; In press

Received	2025-03-17 08:10
Peer-Review Started	2025-03-17 08:11
To Make the First Decision
Return for Revision	2025-04-08 07:54
Revised	2025-04-30 10:16
Second Decision	2025-06-26 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-26 08:58
Articles in Press	2025-06-26 08:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
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