Publication Name	World Journal of Stem Cells
Manuscript ID	107153
Country	Oman

Category	Ophthalmology
Manuscript Type	Minireviews
Article Title	When hematology meets ophthalmology: Cytomegalovirus retinitis in pediatric stem cell recipients
Manuscript Source	Invited Manuscript
All Author List	Aisha Al-Battashy and Nouf Al-Farsi
Funding Agency and Grant Number
Corresponding Author	Nouf Al-Farsi, Chief Physician, FRCS, MD, Department of Ophthalmology, Sultan Qaboos University, P.O. Box 38 P.C. 123 Al-Khoud, Muscat 123, Oman. noufalfarsi@gmail.com
Key Words	Cytomegalovirus retinitis; Pediatric stem cell transplant; Hematopoietic stem cell transplantation; Cytomegalovirus viremia; Ocular complications; Antiviral therapy; Immune reconstitution; T-cell therapy; Screening protocols
Core Tip	Cytomegalovirus retinitis in pediatric hematopoietic stem cell transplant recipients is a complex and potentially devastating complication, but with early detection and appropriate management, outcomes can be significantly improved. Screening protocols continue to evolve, with the emphasis on identifying high-risk patients during periods of immune reconstitution. Management of cytomegalovirus retinitis in pediatric patients post-hematopoietic stem cell transplant requires a comprehensive approach that balances effective viral suppression with the mitigation of drug-related toxicities. Antiviral therapies, whether systemic, intravitreal, or implantable, remain central to treatment. Adjunctive immunotherapies, particularly adoptive T-cell therapy, offer promising outcomes in refractory cases. Emerging modalities, including high-dose intravitreal regimens and novel antivirals, hold potential for future advancements. Individualized treatment plans, guided by patient-specific risk factors and disease severity, are crucial for optimizing outcomes and preserving vision in this vulnerable population.
Citation	Al-Battashy A, Al-Farsi N. When hematology meets ophthalmology: Cytomegalovirus retinitis in pediatric stem cell recipients. World J Stem Cells 2025; In press

Received	2025-03-17 03:52
Peer-Review Started	2025-03-24 00:11
To Make the First Decision
Return for Revision	2025-04-30 07:34
Revised	2025-05-11 17:14
Second Decision	2025-06-18 05:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-19 08:53
Articles in Press	2025-06-19 08:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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