Publication Name	World Journal of Methodology
Manuscript ID	107203
Country	India

Category	Rehabilitation
Manuscript Type	Observational Study
Article Title	Comparative effectiveness of amitriptyline vs duloxetine in the treatment of chronic low back pain: An observational study
Manuscript Source	Invited Manuscript
All Author List	Nityananda Sardar, Raktim Swarnakar, Soumyadipta Ghosh and Pankaj Kumar Mandal
Funding Agency and Grant Number
Corresponding Author	Raktim Swarnakar, Assistant Professor, MD, Faculty of Physical Medicine and Rehabilitation, National Cancer Insitute, Jhajjar Campus, All India Institute of Medical Sciences (AIIMS), New Delhi, New Delhi 110029, Delhi, India. raktimswarnakar@hotmail.com
Key Words	Amitriptyline; Duloxetine; Chronic low back pain; Neuropathic pain; Pain
Core Tip	This study compared the efficacy and safety of Amitriptyline and Duloxetine in treating chronic low back pain (CLBP). Both medications were effective in reducing pain, as evidenced by statistically significant improvements in the visual analog scale at 1, 4, and 12 weeks. However, Duloxetine demonstrated a more favorable side effect profile and better long-term sustained effects compared to Amitriptyline, with fewer anticholinergic and sedative effects. These findings suggest that while both drugs are viable options for CLBP management, Duloxetine may be preferred for patients seeking a treatment with fewer side effects. The choice of medication should be individualized based on patient-specific factors and health conditions.
Citation	Sardar N, Swarnakar R, Ghosh S, Mandal PK. Comparative effectiveness of amitriptyline vs duloxetine in the treatment of chronic low back pain: An observational study. World J Methodol 2025; In press

Received	2025-03-19 02:02
Peer-Review Started	2025-03-27 09:20
To Make the First Decision
Return for Revision	2025-05-12 03:49
Revised	2025-05-15 13:56
Second Decision	2025-08-15 02:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 06:38
Articles in Press	2025-08-15 06:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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