Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	107235
Country	China

Category	Genetics & Heredity
Manuscript Type	Case Report
Article Title	Hereditary chronic intestinal pseudo-obstruction caused by a rare MYH11 mutation: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Shan Jiang, Ya-Xuan Zhou, Xiao-Hong Sun, Pei-Pei Chen, Hao Tang, Yang Chen, Ya-Ping Liu, Yi-Xuan Li and Lin Kang
Funding Agency and Grant Number	Funding Agency Grant Number National High Level Hospital Clinical Research Funding 2022-PUMCH-B-129
Corresponding Author	Lin Kang, Chief Physician, MD, PhD, Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. kangl@pumch.cn
Key Words	Rare disease; Chronic intestinal pseudo-obstruction; Gastrointestinal motility disorder; MYH11; Case report
Core Tip	Chronic intestinal pseudo-obstruction (CIPO) is a rare disorder, characterized by severe impairments of gastrointestinal motility. This case involves an elderly male with an insidious onset during adolescence and a disease course spanning several decades, who experienced two episodes of intestinal obstruction requiring ileocecal resection. The histopathological findings confirmed the diagnosis of CIPO. Whole-exome sequencing identified a rare heterozygous MYH11 mutation [NM_001040113.2: C.5819del (p.Pro1940HisfsTer91)], confirming the diagnosis of hereditary myopathic CIPO. This case provides evidence to support the role of MYH11 variants in the CIPO phenotype.
Citation	Jiang S, Zhou YX, Sun XH, Chen PP, Tang H, Chen Y, Liu YP, Li YX, Kang L. Hereditary chronic intestinal pseudo-obstruction caused by a rare MYH11 mutation: A case report. World J Gastrointest Surg 2025; In press

Received	2025-03-19 13:04
Peer-Review Started	2025-03-19 13:04
To Make the First Decision
Return for Revision	2025-03-30 01:07
Revised	2025-04-12 04:42
Second Decision	2025-05-09 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-09 08:29
Articles in Press	2025-05-09 08:29
Publication Fee Transferred	2025-04-14 08:25
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Typeset the Manuscript

ISSN	1948-9366 (online)
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