Publication Name	World Journal of Diabetes
Manuscript ID	107256
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Study
Article Title	Chronic hepatitis B with type 2 diabetes mellitus: Association between glycemic control and liver fibrosis
Manuscript Source	Invited Manuscript
All Author List	Yan Luo, Rui Li, Jun Kang, Ben-Nan Zhao, Li-Juan Lan, Feng-Jiao Gao, Xiao-Xia Ren, Yan-Feng Zhu and Da-Feng Liu
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Sichuan Province 2023NSFSC0682
Corresponding Author	Da-Feng Liu, Chief Physician, MD, PhD, The First Ward of Internal Medicine, Public Health Clinical Center of Chengdu, No. 18 Jingjushi Road, Jinjiang District, Chengdu 610066, Sichuan Province, China. ldf312@126.com
Key Words	Chronic hepatitis B; Type 2 diabetes mellitus; Liver fibrosis; Hypoglycemic agents; Glycemic control status
Core Tip	This study found that fasting blood glucose significantly mediated the progression of hepatic fibrosis in patients with both chronic hepatitis B and type 2 diabetes mellitus, via the alanine aminotransferase/aspartate aminotransferase pathway. Albumin and gamma-glutamyl transferase levels varied among groups with differing glycemic status, while fibrinogen, the international normalized ratio, serum ferritin, type III procollagen N-terminal peptide, aspartate aminotransferase, prothrombin time, and thromboplastin activity were associated with glycemic levels. These findings indicate that both hepatic impairment and coagulation dysfunction influence glycemic control, and that stringent glycemic management along with the administration of hypoglycemic agents may lower the risk of fibrosis.
Citation	Luo Y, Li R, Kang J, Zhao BN, Lan LJ, Gao FJ, Ren XX, Zhu YF, Liu DF. Chronic hepatitis B with type 2 diabetes mellitus: Association between glycemic control and liver fibrosis. World J Diabetes 2025; In press

Received	2025-03-20 15:33
Peer-Review Started	2025-03-24 00:08
To Make the First Decision
Return for Revision	2025-04-17 03:57
Revised	2025-04-30 10:46
Second Decision	2025-06-03 10:28
Accepted by Journal Editor-in-Chief	2025-06-08 15:32
Accepted by Executive Editor-in-Chief	2025-06-16 10:37
Articles in Press	2025-06-16 10:37
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ISSN	1948-9358 (online)
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