Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	107259
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Targeting probiotic modulation of gut microbiota for postoperative depression management in patients undergoing gastric cancer surgery
Manuscript Source	Invited Manuscript
All Author List	Yao Peng, Man-Ying Xie, Ling Gan and Jia-Qi Zhang
Funding Agency and Grant Number
Corresponding Author	Jia-Qi Zhang, Associate Professor, MD, PhD, Department of Ultrasound Imaging, Postgraduate Union Training Base of Xiangyang No.1 People's Hospital, Xiangyang 441000, Hubei Province, China. 347235272@qq.com
Key Words	Gut microbiota; Probiotics; Postoperative depression; Gastric cancer; Psychotropic therapy; Holistic recovery
Core Tip	Post-gastric cancer surgery, depression critically impacts recovery. Combining Bifidobacterium triple viable bacteria with mirtazapine reduced Self-Rating Depression Scale depression scores by 32%, improved neuroendocrine markers, and modulated gut microbiota. Integrating these interventions with psychological support and lifestyle changes optimizes patient adaptation and long-term well-being.
Citation	Peng Y, Xie MY, Gan L, Zhang JQ. Targeting probiotic modulation of gut microbiota for postoperative depression management in patients undergoing gastric cancer surgery. World J Gastrointest Surg 2025; In press

Received	2025-03-19 11:28
Peer-Review Started	2025-03-19 11:28
To Make the First Decision
Return for Revision	2025-04-03 08:48
Revised	2025-04-03 18:59
Second Decision	2025-05-20 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-20 04:04
Articles in Press	2025-05-20 04:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-05-22 12:22
Typeset the Manuscript

ISSN	1948-9366 (online)
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