Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	107341
Country	Pakistan

Category	Oncology
Manuscript Type	Minireviews
Article Title	Role of interleukins pathogenesis in cholangiocarcinoma: A literature review
Manuscript Source	Invited Manuscript
All Author List	Saira Rafaqat, Hafsa Hamid, Roha Asif, Muhammad Asif, Maria Tariq, Malaika Saleem and Hijab Abaid
Funding Agency and Grant Number
Corresponding Author	Saira Rafaqat, PhD, Department of Zoology, Lahore College for Women University, Jail Rd, Near Wapda Flats, Lahore 54000, Pakistan. saera.rafaqat@gmail.com
Key Words	Cholangiocarcinoma; Intrahepatic cholangiocarcinoma; Interleukins; Pathogenesis
Core Tip	Interleukins (IL) contribute to cholangiocarcinoma (CCA) pathogenesis by promoting chronic inflammation, enhancing tumor cell survival, proliferation, and invasion, and shaping a tumor microenvironment that supports cancer growth and metastasis. ILs, which are a group of cytokines, play a crucial role in mediating the immune response and inflammation. This article concludes that IL-1, IL-4, IL-6, IL-8, IL-10, IL-17, IL-23, IL-25, IL-33 and IL-35 play significant roles in the pathogenesis of CCA. Further research is required to find the association of other ILs such as IL-3, IL-5, IL-7, IL-11 and more in the pathogenesis of CCA.
Citation	Rafaqat S, Hamid H, Asif R, Asif M, Tariq M, Saleem M, Abaid H. Role of interleukins pathogenesis in cholangiocarcinoma: A literature review. World J Gastrointest Oncol 2025; In press

Received	2025-03-21 16:46
Peer-Review Started	2025-03-21 16:46
To Make the First Decision
Return for Revision	2025-04-25 09:07
Revised	2025-04-27 04:51
Second Decision	2025-06-06 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-06 07:11
Articles in Press	2025-06-06 07:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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