| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hua-Yue Wu, Lu Han, Tao Ran, Yong Sun, Qing-Xiu Zhang, Tao Huang, Gao-Liang Zou, Ya Zhang, Yu-Mei Zhou, Guo-Yuan Lin, Shao-Jie Chen, Jing-Lin Wang, Chen Pan, Fan Lu, Hong-Fei Pu and Xue-Ke Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Science and Technology Program of the Guizhou Province |
[2021]094 |
| National Natural Science Foundation of China |
82060116 |
| the Guizhou Provincial Science and Technology Program |
QKHJC-ZK[2023]214 |
| Doctoral Research Start-up Fund Project of Guizhou Medical University |
gyfybsky[2021]63 |
| National Natural Science Foundation of China |
82260129 |
|
| Corresponding Author |
Xue-Ke Zhao, MD, Department of Infectious Diseases, Affiliated Hospital of Guizhou Medical University,Guizhou Medical University, No. 9 Beijing Road, Guiyang 550004, Guizhou Province, China. zhaoxueke1@163.com |
| Key Words |
Liver fibrosis; Hepatic stellate cells; Focal adhesion kinase; Aerobic glycolysis; Fructose-1,6-bisphosphatase |
| Core Tip |
In this study, we show that focal adhesion kinase (FAK) inhibitors suppress hepatic stellate cells (HSCs) activation and aerobic glycolysis, thereby alleviating liver fibrosis (LF). FBP1 inhibits HSCs activation and migration by regulating aerobic glycolysis. FAK can affect the expression of FBP1. Therefore, both FAK and FBP1 may serve as potential therapeutic targets for LF. |
| Citation |
Wu HY, Han L, Ran T, Sun Y, Zhang QX, Huang T, Zou GL, Zhang Y, Zhou YM, Lin GY, Chen SJ, Wang JL, Pan C, Lu F, Pu HF, Zhao XK. FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation. World J Gastroenterol 2025; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
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|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
