Publication Name	World Journal of Cardiology
Manuscript ID	107386
Country	India

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Impact of gut microbiome on atrial fibrillation: Mechanistic insights and future directions in individualized medicine
Manuscript Source	Invited Manuscript
All Author List	Ajit Singh Brar, Shree Laya Vemula, Vishnu Yanamaladoddi, Sohail Sodhi, Juniali Hatwal, Aalam Sohal and Akash Batta
Funding Agency and Grant Number
Corresponding Author	Akash Batta, Associate Professor, Department of Cardiology, Dayanand Medical College and Hospital, Tagore Nagar, Civil Lines, Ludhiana 141001, Punjab, India. akashbatta02@gmail.com
Key Words	Atrial fibrillation; Gut microbiome; Dysbiosis; Inflammation; Short-chain-fatty-acid; Trimethylamine N-oxide; Ferroptosis; Lipopolysaccharides; Microbiome-based therapy; Individualized care
Core Tip	Gut microbiome alteration contributes to the generation of harmful metabolites, loss of gut integrity, and cardiac remodeling. Gut dysbiosis interacts with modifiable risk factors to promote cardiac tissue remodeling. Animal models and clinical studies indicate that microbial composition is associated with arrhythmogenesis, atrial fibrillation (AF) recurrence, and modulates medication response. Integrating microbiome surveillance and gut microbiome modulation therapy into AF management may slow disease progression and reduce the arrhythmia burden. However, clinical trials are needed to establish causality and support the incorporation of gut modulation into clinical care.
Citation	Brar AS, Vemula SL, Yanamaladoddi V, Sodhi S, Hatwal J, Sohal A, Batta A. Impact of gut microbiome on atrial fibrillation: Mechanistic insights and future directions in individualized medicine. World J Cardiol 2025; In press

Received	2025-03-24 07:03
Peer-Review Started	2025-03-24 07:03
To Make the First Decision
Return for Revision	2025-03-28 09:49
Revised	2025-04-11 11:36
Second Decision	2025-05-13 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-13 09:55
Articles in Press	2025-05-13 09:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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