Publication Name	World Journal of Psychiatry
Manuscript ID	107404
Country	China

Category	Psychiatry
Manuscript Type	Review
Article Title	Cell-free DNA in extracellular vesicles: A candidate biomarker of schizophrenia
Manuscript Source	Invited Manuscript
All Author List	Yu-Long Bai, Shi-Fa Ma, Dong-Dong Qi, Chuang Guo, Peng Liu and Kuan-Jun He
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Inner Mongolia Autonomous Region 2024LHMS08003 Science and Technology Program of the Joint Fund of Scientific Research for the Public Hospitals of Inner Mongolia Academy of Medical Sciences 2024GLLH0844
Corresponding Author	Kuan-Jun He, PhD, Professor, College of Life Sciences and Food Engineering, Inner Mongolia Minzu University, No. 996 Xilamulun Street, Tongliao 028000, Inner Mongolia Autonomous Region, China. hekuanjun@imun.edu.cn
Key Words	Schizophrenia; Cell-free DNA; Extracellular vesicles; Mitochondrial damage; Inflammation
Core Tip	Schizophrenia (SCZ) is a severe mental disorder characterized by multi-dimensional dysfunction in perception, cognition, emotion, and behavior. Recent research has highlighted the critical role of cell-free DNA (cf-DNA) carried by extracellular vesicles in SCZ. Abnormal expression of cf-DNA may be potentially linked to the pathological progression of SCZ. This review provides the molecular regulatory mechanisms of extracellular vesicle-derived cf-DNA in the pathogenesis and progression of SCZ, emphasizing its potential as a novel diagnostic marker and its promising clinical applications, thereby offering a new avenue for exploring the biological underpinnings of the disease and developing objective diagnostic tools.
Citation	Bai YL, Ma SF, Qi DD, Guo C, Liu P, He KJ. Cell-free DNA in extracellular vesicles: A candidate biomarker of schizophrenia. World J Psychiatry 2025; In press

Received	2025-03-24 04:39
Peer-Review Started	2025-03-25 02:33
To Make the First Decision
Return for Revision	2025-04-07 12:29
Revised	2025-04-19 02:01
Second Decision	2025-06-20 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-20 09:26
Articles in Press	2025-06-20 09:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-06-23 19:12
Typeset the Manuscript

ISSN	2220-3206 (online)
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