Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	107412
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of circulating tumor DNA methylation in gastric cancer initiation and progression: A comprehensive review
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Yu Huang, Jiang Lan and Wei Zhuang
Funding Agency and Grant Number
Corresponding Author	Wei Zhuang, MD, Intensive Care Medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No.1 Jingbaji Road, Shizhong District, Jinan 250000, Shandong Province, China. 18364155005@163.com
Key Words	Gastric neoplasms; DNA methylation; Circulating tumor DNA; Biomarkers; Early screening
Core Tip	Circulating tumor DNA (ctDNA) has emerged as a promising noninvasive biomarker for early cancer detection and monitoring. Aberrant DNA methylation is one of the earliest and most frequent epigenetic alterations in gastric cancer. This review summarizes recent advances in understanding the role of ctDNA methylation in gastric cancer initiation, progression, and potential clinical applications. We highlight the advantages of ctDNA methylation analysis in disease diagnosis, prognosis prediction, and therapeutic monitoring. A better understanding of ctDNA methylation dynamics may provide new insights into personalized medicine and improve outcomes in patients with gastric cancer.
Citation	Huang HY, Lan J, Zhuang W. Role of circulating tumor DNA methylation in gastric cancer initiation and progression: A comprehensive review. World J Gastrointest Oncol 2025; In press

Received	2025-03-26 03:26
Peer-Review Started	2025-03-26 03:26
To Make the First Decision
Return for Revision	2025-04-09 11:09
Revised	2025-05-05 10:52
Second Decision	2025-06-19 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-19 07:00
Articles in Press	2025-06-19 07:00
Publication Fee Transferred	2025-05-13 06:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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