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Publication Name World Journal of Stem Cells
Manuscript ID 107480
Country Egypt
Category Medicine, Research & Experimental
Manuscript Type Review
Article Title Current perspectives on regenerative potential of mesenchymal stem cells in alleviating cardiac injuries: Molecular pathways and therapeutic enhancement
Manuscript Source Invited Manuscript
All Author List Asmaa M ShamsEldeen, Sara A Hosny, Khaled A Maghib and Hend A Ashour
Funding Agency and Grant Number
Corresponding Author Asmaa M ShamsEldeen, Assistant Professor, MD, Department of Physiology, Cairo University, Al-Saray Street, Cairo 11956, Egypt. asmaa82shamseldeen@gmail.com
Key Words Stem cells; Homing; Paracrine effects; Extracellular vesicles; Cardiac damage
Core Tip In clinical and experimental research, mesenchymal stem cells (MSCs) are currently thought to exert a promising therapeutic potential. Globally, cardiovascular diseases remain the leading cause of mortality. Thus, studying the specific molecular pathways by which MSCs mitigate cardiac injuries is essential in improving their therapeutic applications in the future. Through their immunoregulatory, anti-apoptotic, antifibrotic, antioxidant, and angiogenic activities, MSCs can influence the course of cardiovascular diseases. Successful homing and engraftment are necessary for MSCs’ regenerative capacity. Meanwhile, this review also focused on the underlying mechanisms of MSCs homing and the challenges that may hinder their effects.
Citation ShamsEldeen AM, Hosny SA, Maghib KA, Ashour HA. Current perspectives on regenerative potential of mesenchymal stem cells in alleviating cardiac injuries: Molecular pathways and therapeutic enhancement. World J Stem Cells 2025; In press
Received
2025-03-25 05:58
Peer-Review Started
2025-03-25 05:59
To Make the First Decision
Return for Revision
2025-04-01 12:42
Revised
2025-04-12 21:36
Second Decision
2025-07-09 09:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-10 07:23
Articles in Press
2025-07-10 07:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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