Publication Name	World Journal of Stem Cells
Manuscript ID	107480
Country	Egypt

Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Current perspectives on regenerative potential of mesenchymal stem cells in alleviating cardiac injuries: Molecular pathways and therapeutic enhancement
Manuscript Source	Invited Manuscript
All Author List	Asmaa M ShamsEldeen, Sara A Hosny, Khaled A Maghib and Hend A Ashour
Funding Agency and Grant Number
Corresponding Author	Asmaa M ShamsEldeen, Assistant Professor, MD, Department of Physiology, Cairo University, Al-Saray Street, Cairo 11956, Egypt. asmaa82shamseldeen@gmail.com
Key Words	Stem cells; Homing; Paracrine effects; Extracellular vesicles; Cardiac damage
Core Tip	In clinical and experimental research, mesenchymal stem cells (MSCs) are currently thought to exert a promising therapeutic potential. Globally, cardiovascular diseases remain the leading cause of mortality. Thus, studying the specific molecular pathways by which MSCs mitigate cardiac injuries is essential in improving their therapeutic applications in the future. Through their immunoregulatory, anti-apoptotic, antifibrotic, antioxidant, and angiogenic activities, MSCs can influence the course of cardiovascular diseases. Successful homing and engraftment are necessary for MSCs’ regenerative capacity. Meanwhile, this review also focused on the underlying mechanisms of MSCs homing and the challenges that may hinder their effects.
Citation	ShamsEldeen AM, Hosny SA, Maghib KA, Ashour HA. Current perspectives on regenerative potential of mesenchymal stem cells in alleviating cardiac injuries: Molecular pathways and therapeutic enhancement. World J Stem Cells 2025; In press

Received	2025-03-25 05:58
Peer-Review Started	2025-03-25 05:59
To Make the First Decision
Return for Revision	2025-04-01 12:42
Revised	2025-04-12 21:36
Second Decision	2025-07-09 09:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-10 07:23
Articles in Press	2025-07-10 07:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com