Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	107482
Country	Taiwan

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	How to distinguish pancreatic tumors and assess the necessity for biopsy
Manuscript Source	Invited Manuscript
All Author List	Ming-Sheng Chien, Ching-Chung Lin and Jian-Han Lai
Funding Agency and Grant Number
Corresponding Author	Jian-Han Lai, MD, Department of Internal Medicine, MacKay Memorial Hospital, No. 92, Sec. 2, Chung-Shan North Road, Taipei 104217, Taiwan. jiannhann@gmail.com
Key Words	Endoscopic ultrasound; Contrast; Elastography; Pancreatic tumor; Fine-needle biopsy
Core Tip	This article highlights the endoscopic ultrasonography, assisted by contrast enhanced sonography and elastography, offers superior accuracy in detecting and characterizing pancreatic tumors. By assessing morphology, vascularity, and tissue stiffness, it differentiates malignant from benign processes and identifies high-risk cystic lesions. Endoscopic ultrasonography-guided fine needle biopsy enables histological and molecular diagnosis, including next generation sequencing for actionable mutations, guiding surgical decisions, neoadjuvant therapy, and targeted treatments. This integrated approach optimizes pancreatic cancer detection, staging, and personalized management while avoiding unnecessary interventions.
Citation	Chien MS, Lin CC, Lai JH. How to distinguish pancreatic tumors and assess the necessity for biopsy. World J Gastrointest Endosc 2025; In press

Received	2025-03-25 07:26
Peer-Review Started	2025-03-31 05:32
To Make the First Decision
Return for Revision	2025-05-12 10:11
Revised	2025-05-26 06:25
Second Decision	2025-09-03 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-03 09:36
Articles in Press	2025-09-03 09:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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