Publication Name	World Journal of Clinical Oncology
Manuscript ID	107490
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Recent progress in the use of periplocin, periplocymarin and periplogenin in cancer treatment
Manuscript Source	Invited Manuscript
All Author List	Xin Sun, Xiao-Wei Shi, Lei Han, Fan-Yi Zhang, Yang Xu and Cheng-Yu Lu
Funding Agency and Grant Number	Funding Agency Grant Number Traditional Chinese Medicine Science and Technology Project of Shandong Province, China No. M-2023131 The Science and Technology Development Fund Project of the Affiliated Hospital of Xuzhou Medical University, China No. XYFM202348
Corresponding Author	Cheng-Yu Lu, PhD, Senior Researcher, Department of Biobank, Linyi People's Hospital, No. 27 Jiefang Road, District Lanshan, Linyi 276000, Shandong Province, China. luyu-20@163.com
Key Words	Periplocin; Periplocymarin; Periplogenin; Cancer therapy; Cortex Periplocae
Core Tip	Periplocin, periplocymarin and periplogenin are three cardiac glycosides widely recognized as the main active ingredients of Cortex Periplocae. Various experiments have shown that they exert antitumor effects by regulating cell cycle proteins, blocking malignant cell proliferation, activating caspase proteases and inducing apoptosis in cancer cells. This minireview focuses on the tumor inhibitory effects of periplocin, periplocymarin and periplogenin.
Citation	Sun X, Shi WX, Han L, Zhang YF, Xu Y, Lu YC. Recent progress in the use of periplocin, periplocymarin and periplogenin in cancer treatment. World J Clin Oncol 2025; In press

Received	2025-03-30 11:43
Peer-Review Started	2025-03-30 11:43
To Make the First Decision
Return for Revision	2025-04-23 11:49
Revised	2025-05-03 08:06
Second Decision	2025-06-26 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-26 07:19
Articles in Press	2025-06-26 07:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com