Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	107492
Country	Türkiye

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Pathophysiology of anastomotic stricture following rectal anastomosis: Insights into mechanisms, risk factors, and preventive strategies
Manuscript Source	Invited Manuscript
All Author List	Ahmet Yavuz, Hikmet Pehlevan-Özel and Mesut Tez
Funding Agency and Grant Number
Corresponding Author	Mesut Tez, Professor, Department of Surgery, University of Health Sciences, Ankara City Hospital, No. 1 Bilkent Street, District of Universities, Ankara 06800, Türkiye. mesuttez@yahoo.com
Key Words	Anastomotic stricture; Rectal cancer; Fibrosis; Inflammation; Anastomotic leakage; Radiotherapy; Ischemia; Surgical technique
Core Tip	Anastomotic stricture following rectal anastomosis is a multifactorial complication driven by fibrosis, inflammation, anastomotic leakage, radiotherapy, and ischemia. This review highlights the pathophysiological mechanisms, including excessive collagen deposition and transforming growth factor-beta activation, and identifies key risk factors such as neoadjuvant radiotherapy and surgical technique. Preventive strategies, such as preserving blood supply and using standardized stapling techniques, are emphasized to improve patient outcomes and reduce stricture incidence.
Citation	Yavuz A, Pehlevan-Özel H, Tez M. Pathophysiology of anastomotic stricture following rectal anastomosis: Insights into mechanisms, risk factors, and preventive strategies. World J Gastrointest Pathophysiol 2025; In press

Received	2025-03-25 05:32
Peer-Review Started	2025-03-25 05:32
To Make the First Decision
Return for Revision	2025-03-28 09:46
Revised	2025-03-28 14:25
Second Decision	2025-05-08 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-08 12:55
Articles in Press	2025-05-08 12:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
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