Publication Name	World Journal of Clinical Oncology
Manuscript ID	107509
Country	Qatar

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Proton pump inhibitors and mortality in cancer patients: Unraveling the complex link
Manuscript Source	Invited Manuscript
All Author List	Ibtehaj Tariq, Qurat Ul Ain Iftikhar and Abdulqadir J Nashwan
Funding Agency and Grant Number
Corresponding Author	Abdulqadir J Nashwan, PhD, Department of Nursing, Hamad Medical Corporation, P.O. Box 3050, Doha 3050, Qatar. anashwan@hamad.qa
Key Words	Proton pump inhibitors; Cancer mortality; Confounding by indication; Reverse causality; Polypharmacy; Gastrointestinal complications; Acid suppression therapy; Clinical pharmacology; Oncology treatment; Observational study
Core Tip	The original study by Krishnan et al proposes a link between proton pump inhibitors use and increased all-cause mortality. Our critique highlights methodological limitations, including residual confounding, indication bias, and a lack of causality assessment. We draw attention to the need for cautious interpretation and advocate for well-designed prospective studies before drawing definitive clinical conclusions.
Citation	Tariq I, Iftikhar QUA, Nashwan AJ. Proton pump inhibitors and mortality in cancer patients: Unraveling the complex link. World J Clin Oncol 2025; In press

Received	2025-03-25 06:35
Peer-Review Started	2025-03-25 06:35
To Make the First Decision
Return for Revision	2025-04-16 10:41
Revised	2025-04-18 07:15
Second Decision	2025-06-05 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-05 08:35
Articles in Press	2025-06-05 08:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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