Publication Name	World Journal of Psychiatry
Manuscript ID	107524
Country	China

Category	Neurosciences
Manuscript Type	Basic Study
Article Title	DNA methylation regulates the extinction of fear memory
Manuscript Source	Unsolicited Manuscript
All Author List	Le Jiang, Rui-Xue Ma, Er-Shu He, Xiao-Ye Zheng, Xin Peng, Wen-Hao Ma, Ying Li, Han-Wei Li, Xue-Yan Zhang, Jie-Yu Ji, Yan-Jiao Li, Shang-Lan Qu, Li-Juan Li and Zhi-Ting Gong
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) 82360231 Yunnan Basic Research Program General Project 202401AT070075 Dali Basic Research Program Key Project 202301A020021 Youth Special Project for Basic Research of Local Universities in Yunnan Province 202301BA070001-127
Corresponding Author	Zhi-Ting Gong, Associate Professor, School of Medicine, Dali university, No. 2 Hongsheng Road, Dali 671003, Yunnan Province, China. gzhting@foxmail.com
Key Words	RG108; DNA methylation; Fear memory; Exposure therapy; Extinction
Core Tip	Reduce methylation by RG108 suppressed extinction, reduced spine density, and inhibited neuronal activity; enhancing methylation by L-methionine improve the efficacy of exposure therapy, offering a potential strategy for treating fear-related disorders.
Citation	Jiang L, Ma RX, He ES, Zheng XY, Peng X, Ma WH, Li Y, Li HW, Zhang XY, Ji JY, Li YJ, Qu SL, Li LJ, Gong ZT. DNA methylation regulates the extinction of fear memory. World J Psychiatry 2025; In press

Received	2025-03-30 10:49
Peer-Review Started	2025-04-06 08:18
To Make the First Decision
Return for Revision	2025-04-09 12:09
Revised	2025-04-23 03:20
Second Decision	2025-05-12 10:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-19 09:23
Articles in Press	2025-05-19 09:23
Publication Fee Transferred	2025-04-24 02:28
Edit the Manuscript by Language Editor	2025-05-27 01:45
Typeset the Manuscript

ISSN	2220-3206 (online)
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