Publication Name	World Journal of Clinical Cases
Manuscript ID	107535
Country	China

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Case Report
Article Title	Mechanism analysis of periostin in osteoclasts differentiation of dental follicle: Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Jun Cai and Han Qin
Funding Agency and Grant Number	Funding Agency Grant Number Xuzhou Medical University Affiliated Hospital Development Fund Support Project Grant number: XYFM202457 521 Scientific Research Project of Lianyungang City LYG 06521202362
Corresponding Author	Han Qin, Professor, Department of Stomatology, The Lianyungang Affiliated Hospital of Xuzhou Medical University/Lianyungang First People's Hospital, No. 182 Tongguan Road, Lianyungang 222002, Jiangsu Province, China. qinhan2005@163.com
Key Words	Tooth eruption disorder; Dental follicle; Osteoclast differentiation; Periostin; Case report
Core Tip	This study analyzed the periostin and bone metabolic factors in the dental follicle and alveolar bone of two patients with tooth eruption disorders. And the results suggest that tooth eruption diseases may be accompanied by abnormal remodeling of periostin, which can affect the differentiation function of osteoclasts in the dental follicle, leading to an imbalance in alveolar bone metabolism and resulting in tooth eruption disorders. This provides some reference for the etiology and treatment of tooth eruption disorders from a new research perspective of the effect of extracellular matrix on the differentiation of osteoclasts in dental follicle.
Citation	Cai J, Qin H. Mechanism analysis of periostin in osteoclasts differentiation of dental follicle: Two case reports. World J Clin Cases 2025; In press

Received	2025-03-26 03:11
Peer-Review Started	2025-03-26 03:11
To Make the First Decision
Return for Revision	2025-04-01 12:53
Revised	2025-04-10 12:00
Second Decision	2025-05-09 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-10 02:06
Articles in Press	2025-05-10 02:06
Publication Fee Transferred	2025-04-14 11:38
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Typeset the Manuscript

ISSN	2307-8960 (online)
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