Publication Name	World Journal of Cardiology
Manuscript ID	107539
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Breaking barriers: Neprilysin inhibition in chronic cardiorenal syndrome
Manuscript Source	Invited Manuscript
All Author List	Olesya Ilkun and Amir Kazory
Funding Agency and Grant Number
Corresponding Author	Amir Kazory, Professor, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, 1600 Sw Archer Rd Box 100224, Gainesville, FL 32610, United States. amir.kazory@medicine.ufl.edu
Key Words	Neprilysin inhibitor; Sacubitril/valsartan; Heart failure; Chronic kidney disease; End-stage kidney disease
Core Tip	Patients with advanced chronic kidney disease and end-stage kidney disease face disproportionally high rates of heart failure and mortality. Currently, there is an unmet need for medical therapies for heart failure in these populations. This review summarizes information regarding the safety and efficacy of the use of angiotensin receptor/neprilysin inhibition in patients with heart failure with reduced ejection fraction and advanced chronic kidney disease or end-stage kidney disease to help guide safe clinical management.
Citation	Ilkun O, Kazory A. Breaking barriers: Neprilysin inhibition in chronic cardiorenal syndrome. World J Cardiol 2025; In press

Received	2025-03-26 03:58
Peer-Review Started	2025-03-26 03:59
To Make the First Decision
Return for Revision	2025-04-25 09:12
Revised	2025-04-29 14:50
Second Decision	2025-06-16 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-16 11:09
Articles in Press	2025-06-16 11:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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