Publication Name	World Journal of Hepatology
Manuscript ID	107541
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Liver immunology: Biological role and clinical significance
Manuscript Source	Invited Manuscript
All Author List	Stanislav Nikolaevich Kotlyarov
Funding Agency and Grant Number
Corresponding Author	Stanislav Nikolaevich Kotlyarov, PhD, Professor, Department of Nurse, Ryazan State Medical University, 9 Vysokovoltnaya, Ryazan 390005, Russia. skmr1@yandex.ru
Key Words	Liver; Immunology; Immunometabolism; Innate immune system; Adaptive immune system; Immune cells; Metabolic dysfunction-associated steatotic liver disease; Biliary diseases; Gut microbiota
Core Tip	The liver is an important organ at the intersection of many metabolic and immune pathways. Immune cells in the liver have a complex regulation that can be impaired in various diseases such as metabolic dysfunction-associated steatotic liver disease, liver cancer, and biliary disorders. Interactions with the gut microbiota play an important role in liver immunology. Effects on immune mechanisms are considered a promising therapeutic target for liver diseases.
Citation	Kotlyarov SN. Liver immunology: Biological role and clinical significance. World J Hepatol 2025; In press

Received	2025-03-26 03:46
Peer-Review Started	2025-03-28 00:12
To Make the First Decision
Return for Revision	2025-04-28 09:21
Revised	2025-05-05 14:38
Second Decision	2025-06-27 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-27 07:22
Articles in Press	2025-06-27 07:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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