Publication Name	World Journal of Hepatology
Manuscript ID	107603
Country	China

Category	Surgery
Manuscript Type	Minireviews
Article Title	Splenectomy and the risk of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Da-Qing Li, Zhen-Yi Lin, Jian-Guo Wang, Rong-Qian Wu, Yu Zhang and Zhao-Qing Du
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82200686
Corresponding Author	Zhao-Qing Du, Academic Editor, MD, PhD, Post Doctoral Researcher, Researcher, Department of Hepatobiliary Surgery, Shaanxi Provincial People’s Hospital, No. 256 West Youyi Road, Xi’an 710068, Shaanxi Province, China. duzhaoqing2007@126.com
Key Words	Splenectomy; Hepatocellular carcinoma; Immune status; Hemodynamics; Pathophysiology
Core Tip	Hypersplenism, a frequent complication of cirrhosis, often requires splenectomy to alleviate conditions like thrombocytopenia and anemia. However, splenectomy may alter immune status and hemodynamics, potentially influencing hepatocellular carcinoma (HCC) development. Post-splenectomy risks, including infections and thrombosis, further complicate outcomes. Current evidence on the splenectomy-HCC relationship remains inconclusive, necessitating further research into pathophysiology and epidemiology. This review examines immune, hemodynamic, and gut microbiota changes post-splenectomy to guide individualized treatment strategies for cirrhotic patients.
Citation	Li DQ, Lin ZY, Wang JG, Wu RQ, Zhang Y, Du ZQ. Splenectomy and the risk of hepatocellular carcinoma. World J Hepatol 2025; In press

Received	2025-03-27 03:53
Peer-Review Started	2025-04-06 08:36
To Make the First Decision
Return for Revision	2025-04-16 10:45
Revised	2025-04-29 07:58
Second Decision	2025-06-20 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-20 09:47
Articles in Press	2025-06-20 09:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-06-23 02:51
Typeset the Manuscript

ISSN	1948-5182 (online)
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