Publication Name	World Journal of Clinical Cases
Manuscript ID	107612
Country	Greece

Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Endocrine dysfunction in homozygous beta-thalassemia: An underrecognized and undertreated consequence of prolonged survival
Manuscript Source	Unsolicited Manuscript
All Author List	Christos Savvidis and Ioannis Ilias
Funding Agency and Grant Number
Corresponding Author	Ioannis Ilias, Department of Endocrinology, Hippocration General Hospital, No. 63 Evrou Street, Athens GR-11527, Greece. iiliasmd@yahoo.com
Key Words	Thalassemia, Endocrine dysfunction; Iron overload; Hypogonadotropic hypogonadism; Adrenal insufficiency; Thyroid dysfunction; Bone disease
Core Tip	Endocrine dysfunction is a major source of long-term morbidity in transfusion-dependent beta-thalassemia. Subtle hypothalamic-pituitary axis abnormalities, such as neurosecretory growth hormone dysfunction and tertiary adrenal insufficiency, may precede overt clinical signs. Pituitary magnetic resonance imaging and dynamic hormone testing improve early detection. Integrating routine endocrine screening into thalassemia care enables timely interventions that can prevent irreversible complications and enhance quality of life.
Citation	Savvidis C, Ilias I. Endocrine dysfunction in homozygous beta-thalassemia: An underrecognized and undertreated consequence of prolonged survival. World J Clin Cases 2025; In press

Received	2025-03-27 02:30
Peer-Review Started	2025-03-27 02:30
To Make the First Decision
Return for Revision	2025-04-11 09:51
Revised	2025-04-17 15:43
Second Decision	2025-05-09 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-10 02:08
Articles in Press	2025-05-10 02:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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