Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	107626
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Correlation between sarcopenia diagnosed by C3SMI criteria and prognosis in esophageal cancer patients after radiotherapy
Manuscript Source	Unsolicited Manuscript
All Author List	De-En Wang, Xiao-Fang Qin and Wei Yang
Funding Agency and Grant Number
Corresponding Author	Wei Yang, Associate Chief Physician, Department of Ultrasound Medicine, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huaiyin District, Huai’an 223300, Jiangsu Province, China. yangwei110501@163.com
Key Words	Esophageal cancer; Sarcopenia; C3SMI; Radiotherapy; Risk factors
Core Tip	This study highlights the significant correlation between sarcopenia (diagnosed using C3SMI criteria) and poor prognosis in esophageal cancer patients undergoing radiotherapy. Key findings reveal that age, body mass index, prealbumin levels, and Karnofsky performance status score are independent risk factors for sarcopenia, while sarcopenia itself, along with tumor differentiation, American Joint Committee on Cancer staging, and serum markers (alpha-fetoprotein, thrombospondin-1, carcinoembryonic antigen), adversely impacts prognosis. These results underscore the importance of early sarcopenia assessment and nutritional intervention in clinical management to improve patient outcomes.
Citation	Wang DE, Qin XF, Yang W. Correlation between sarcopenia diagnosed by C3SMI criteria and prognosis in esophageal cancer patients after radiotherapy. World J Gastrointest Oncol 2025; In press

Received	2025-04-22 09:39
Peer-Review Started	2025-04-22 09:39
To Make the First Decision
Return for Revision	2025-05-15 01:57
Revised	2025-05-25 16:08
Second Decision	2025-07-30 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-30 07:00
Articles in Press	2025-07-30 07:00
Publication Fee Transferred	2025-05-26 08:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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