Publication Name	World Journal of Gastroenterology
Manuscript ID	107665
Country	Netherlands

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Considerations and clinical utility of referral pathways for early detection of liver disease in at-risk populations
Manuscript Source	Invited Manuscript
All Author List	Jesse Pustjens, Willem P Brouwer, Ibrahim Ayada, Harry L A Janssen and Laurens A van Kleef
Funding Agency and Grant Number
Corresponding Author	Laurens A van Kleef, MD, PhD, Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Room Na-606, Postbus 2040, Rotterdam 3000, Zuid-Holland, Netherlands. l.vankleef@erasmusmc.nl
Key Words	Epidemiology; General population; Advanced liver disease; Fibrosis; Screening
Core Tip	Early detection of liver fibrosis in community settings is essential to timely intervene and prevent liver related events. Although non-invasive testing strategies are likely to be cost-effective, their uptake by non-hepatology specialists is limited. Key challenges include the use of overly broad target populations and suboptimal selection or application of non-invasive tests (NITs). Optimizing these pathways by integrating better NITs and refining referral algorithms can improve risk stratification, minimize unnecessary specialist referrals, reduce the burden on healthcare systems, and facilitate timely, multidisciplinary care for individuals at highest risk of liver related adverse outcomes.
Citation	Pustjens J, Brouwer WP, Ayada I, Janssen HLA, van Kleef LA. Considerations and clinical utility of referral pathways for early detection of liver disease in at-risk populations. World J Gastroenterol 2025; In press

Received	2025-03-30 11:31
Peer-Review Started	2025-03-30 11:31
To Make the First Decision
Return for Revision	2025-05-12 19:31
Revised	2025-06-18 18:27
Second Decision	2025-08-22 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-22 07:09
Articles in Press	2025-08-22 07:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-08-30 06:24
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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