Publication Name	World Journal of Hepatology
Manuscript ID	107668
Country	Mexico

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Triglyceride-glucose-waist circumference index: A powerful tool for metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Invited Manuscript
All Author List	Bryan Adrian Priego-Parra, Berenice M Román-Calleja, Rocio Gallego-Duran, Jordi Gracia-Sancho, Jose Antonio Velarde Ruiz-Velasco and Jose Maria Remes-Troche
Funding Agency and Grant Number
Corresponding Author	Bryan Adrian Priego-Parra, MD, PhD, Department of Digestive Physiology and Gastrointestinal Motility, Institute of Medical-Biological Research, Universidad Veracruzana, Iturbide S/N Entre Carmen Serdán y 20 de Noviembre, Veracruz 91700, Mexico. bryanpriegop@gmail.com
Key Words	Steatotic liver disease; Liver steatosis; Non-invasive; Biomarkers; Nutritional therapy; Cardiometabolic risk
Core Tip	The search for reliable biomarkers for metabolic dysfunction-associated steatotic liver disease (MASLD) remains a critical priority. Among non-invasive and accessible tools, the triglyceride-glucose-waist circumference index (TyG-WC) has emerged as a particularly robust marker, demonstrating superior diagnostic performance compared with other indices. Its utility extends beyond MASLD, offering valuable insights into cardiovascular risk and other extrahepatic manifestations. Given its simplicity and affordability, the TyG-WC index holds significant promise, particularly in low-resource settings. Nonetheless, longitudinal studies are needed to validate its predictive capacity and guide clinical implementation. Integrating this index within clinical and research frameworks, alongside investigations into the gut microbiota, multiomic profiling, and artificial intelligence, may unlock new pathways for improving MASLD diagnosis and management.
Citation	Priego-Parra BA, Román-Calleja BM, Gallego-Duran R, Gracia-Sancho J, Velarde Ruiz-Velasco JA, Remes-Troche JM. Triglyceride-glucose-waist circumference index: A powerful tool for metabolic dysfunction-associated steatotic liver disease. World J Hepatol 2025; In press

Received	2025-03-30 11:29
Peer-Review Started	2025-03-30 11:29
To Make the First Decision
Return for Revision	2025-04-21 18:38
Revised	2025-05-04 14:39
Second Decision	2025-06-25 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-25 08:23
Articles in Press	2025-06-25 08:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-06-28 20:05
Typeset the Manuscript

ISSN	1948-5182 (online)
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