Publication Name	World Journal of Diabetes
Manuscript ID	107673
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Extra-renal role of urate transporter-1 in diabetes
Manuscript Source	Invited Manuscript
All Author List	Tian-Shu Yang, Min Du, Ling-Yun Luo, Li Lin and Xue-Lian Luo
Funding Agency and Grant Number
Corresponding Author	Xue-Lian Luo, MD, PhD, Department of Oncology, The Third Affiliated Hospital of Chongqing Medical University, Huixing Street, Yubei District, Chongqing 401120, China. 806850653@qq.com
Key Words	Diabetes mellitus; Insulin resistance; Extra-renal urate transporter-1; Urate transporter-1 inhibitor
Core Tip	Emerging evidence highlights the extra-renal roles of urate transporter-1 (URAT1) in diabetes mellitus, extending beyond its canonical function in renal urate reabsorption. URAT1-mediated uric acid uptake in tissues such as adipose, liver, heart, endothelium, and hematopoietic cells exacerbates insulin resistance, oxidative stress, and inflammation, driving diabetic complications. Pharmacological inhibition of URAT1 with agents like dotinurad, benzbromarone, or probenecid attenuates these pathological processes by reducing uric acid influx, restoring insulin signaling, and suppressing pro-inflammatory pathways. This review underscores URAT1 as a pivotal therapeutic target for mitigating multi-organ dysfunction in diabetes mellitus, offering novel strategies to address systemic metabolic and inflammatory derangements.
Citation	Yang TS, Du M, Luo LY, Lin L, Luo XL. Extra-renal role of urate transporter-1 in diabetes. World J Diabetes 2025; In press

Received	2025-03-28 03:56
Peer-Review Started	2025-03-31 00:21
To Make the First Decision
Return for Revision	2025-04-15 03:59
Revised	2025-04-20 15:53
Second Decision	2025-05-29 07:41
Accepted by Journal Editor-in-Chief	2025-05-29 08:15
Accepted by Executive Editor-in-Chief	2025-06-03 08:10
Articles in Press	2025-06-03 08:10
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ISSN	1948-9358 (online)
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