Publication Name	World Journal of Stem Cells
Manuscript ID	107689
Country	China

Category	Cell Biology
Manuscript Type	Review
Article Title	Neural crest-derived mesenchymal stem cells: Fates and perspectives
Manuscript Source	Invited Manuscript
All Author List	Yi-Lin He, Si-Jia Chen, Deng-Sheng Xia and Wen-Peng Song
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82270951
Corresponding Author	Wen-Peng Song, DDS, Postdoc, Department of Stomatology, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing 100070, China. 15011482782@163.com
Key Words	Neural crest; Mesenchymal stem cell; Development; Pluripotent stem cell; Clinical trials
Core Tip	Recent studies have revealed the distribution and functions of neural crest (NC)-derived mesenchymal stem cells (MSCs) in various tissues, with regenerative therapies based on these cells showing positive results in research and clinical practice. Future research focuses on optimizing therapeutic strategies (timing, dosage), expanding clinical applications, and addressing current challenges. Several approaches aim to solve issues like insufficient cell numbers, heterogeneity, and trauma. Notably, MSCs differentiated from pluripotent stem cells via NC pathways show promise as a stable NC-derived MSC source, potentially overcoming current limitations in clinical applications.
Citation	He YL, Chen SJ, Xia DS, Song WP. Neural crest-derived mesenchymal stem cells: Fates and perspectives. World J Stem Cells 2025; In press

Received	2025-03-28 04:15
Peer-Review Started	2025-03-28 04:15
To Make the First Decision
Return for Revision	2025-04-11 09:48
Revised	2025-04-25 16:13
Second Decision	2025-08-06 07:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-08 07:19
Articles in Press	2025-08-08 07:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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