Publication Name	World Journal of Diabetes
Manuscript ID	107693
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Current status and mechanistic insights into nontarget coronary lesions in patients with diabetes and early abnormal glucose metabolism
Manuscript Source	Invited Manuscript
All Author List	Shi-Qi Liu, Dong Wang and Cheng-Chun Tang
Funding Agency and Grant Number
Corresponding Author	Dong Wang, Department of Cardiology, Zhongda Hospital, Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing 210009, Jiangsu Province, China. wangdong_seu@163.com
Key Words	Nontarget lesion; Nonculprit lesion; Diabetes mellitus; Glucose metabolism abnormalities; Oxidative stress; Endothelial dysfunction
Core Tip	The number of nontarget-related recurrent cardiovascular events is increasing. Poor glycemic control, insulin use, and dyslipidemia contribute to high-risk plaque progression. Early glucose metabolism abnormalities and glycemic fluctuations further increase cardiovascular risk. This review examines the clinical and plaque characteristics of these patients with diabetes and early glucose metabolism abnormalities, PCI strategies for nontarget lesions, and the mechanistic roles of inflammation, hypercoagulability, oxidative stress, and endothelial dysfunction in adverse cardiovascular outcomes.
Citation	Liu SQ, Wang D, Tang CC. Current status and mechanistic insights into nontarget coronary lesions in patients with diabetes and early abnormal glucose metabolism. World J Diabetes 2025; In press

Received	2025-04-01 15:38
Peer-Review Started	2025-04-02 06:50
To Make the First Decision
Return for Revision	2025-04-27 05:57
Revised	2025-05-10 18:03
Second Decision	2025-07-17 09:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-30 08:13
Articles in Press	2025-07-30 08:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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