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Publication Name World Journal of Stem Cells
Manuscript ID 107717
Country China
Category Neurosciences
Manuscript Type Review
Article Title Therapeutic potential of mesenchymal stem cells in neurodegenerative diseases
Manuscript Source Invited Manuscript
All Author List Chen-Xu Cui, Xiao-Nan Shao, Yang-Yang Li, Liang Qiao, Jun-Tang Lin and Li-Hong Guan
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Henan Province 242300421199, 252300421395
Henan Province Joint Fund for Science and Technology Research and Development 235101610002
Key Technologies R&D Program of Henan Province 242102310134
Henan Province Foundation for University Key Teacher 2024GGJS088
Corresponding Author Li-Hong Guan, Assistant Professor, PhD, Stem Cells and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, No. 601 Jinsui Road, Xinxiang 453003, Henan Province, China. lhguan2010@163.com
Key Words Mesenchymal stem cells; Neurodegenerative disease; Stem cell therapy; Immunomodulation; Paracrine
Core Tip This review emphasizes the incidence and social burden of neurodegenerative diseases, focusing on the pathogenesis of these diseases and available therapeutic approaches. We have thoroughly investigated the potential of mesenchymal stem cells for use in treating neurodegenerative diseases and explored their therapeutic effects on different diseases. This review aims to elucidate how mesenchymal stem cells can alleviate the progression of neurodegenerative diseases by modulating molecular pathways related to abnormal protein accumulation, neuroinflammation, oxidative stress, and neuroregeneration.
Citation Cui CX, Shao XN, Li YY, Qiao L, Lin JT, Guan LH. Therapeutic potential of mesenchymal stem cells in neurodegenerative diseases. World J Stem Cells 2025; In press
Received
2025-04-01 14:56
Peer-Review Started
2025-04-01 14:57
To Make the First Decision
Return for Revision
2025-04-16 10:39
Revised
2025-04-30 08:19
Second Decision
2025-07-03 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-04 10:06
Articles in Press
2025-07-04 10:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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