Publication Name	World Journal of Stem Cells
Manuscript ID	107717
Country	China

Category	Neurosciences
Manuscript Type	Review
Article Title	Therapeutic potential of mesenchymal stem cells in neurodegenerative diseases
Manuscript Source	Invited Manuscript
All Author List	Chen-Xu Cui, Xiao-Nan Shao, Yang-Yang Li, Liang Qiao, Jun-Tang Lin and Li-Hong Guan
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Henan Province 242300421199, 252300421395 Henan Province Joint Fund for Science and Technology Research and Development 235101610002 Key Technologies R&D Program of Henan Province 242102310134 Henan Province Foundation for University Key Teacher 2024GGJS088
Corresponding Author	Li-Hong Guan, Assistant Professor, PhD, Stem Cells and Biotherapy Technology Research Center of Henan, School of Life Science and Technology, Xinxiang Medical University, No. 601 Jinsui Road, Xinxiang 453003, Henan Province, China. lhguan2010@163.com
Key Words	Mesenchymal stem cells; Neurodegenerative disease; Stem cell therapy; Immunomodulation; Paracrine
Core Tip	This review emphasizes the incidence and social burden of neurodegenerative diseases, focusing on the pathogenesis of these diseases and available therapeutic approaches. We have thoroughly investigated the potential of mesenchymal stem cells for use in treating neurodegenerative diseases and explored their therapeutic effects on different diseases. This review aims to elucidate how mesenchymal stem cells can alleviate the progression of neurodegenerative diseases by modulating molecular pathways related to abnormal protein accumulation, neuroinflammation, oxidative stress, and neuroregeneration.
Citation	Cui CX, Shao XN, Li YY, Qiao L, Lin JT, Guan LH. Therapeutic potential of mesenchymal stem cells in neurodegenerative diseases. World J Stem Cells 2025; In press

Received	2025-04-01 14:56
Peer-Review Started	2025-04-01 14:57
To Make the First Decision
Return for Revision	2025-04-16 10:39
Revised	2025-04-30 08:19
Second Decision	2025-07-03 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-04 10:06
Articles in Press	2025-07-04 10:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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