Publication Name	World Journal of Stem Cells
Manuscript ID	107770
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Nutrient sensing in intestinal stem cell: Linking dietary nutrients to cellular metabolic regulation
Manuscript Source	Invited Manuscript
All Author List	Wen-Hao Li, Xin-Yi Yuan, Zhe Wang and Rong Lin
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Technology of China 2022YFF1203300 National Key Research and Development Program 2023YFC2307001 China Postdoctoral Science Foundation 2023TQ0125, 2024M751031
Corresponding Author	Rong Lin, Professor, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. 2009xh0877@hust.edu.cn
Key Words	Intestinal stem cell; Intestinal organoids; Nutrient sensing; Metabolic regulation; Mitochondria
Core Tip	Diet and nutrition play a critical role in health by regulating intestinal nutrient absorption, with intestinal stem cells serving as the central link between nutrient metabolism and intestinal tissue renewal. Nutrient sensing, metabolic regulation, and mitochondrial function are key determinants of intestinal stem cell fate, balancing self-renewal and differentiation. Understanding these mechanisms offers insights into stem cell-based therapies for gastrointestinal diseases and dietary interventions to promote health.
Citation	Li WH, Yuan XY, Wang Z, Lin R. Nutrient sensing in intestinal stem cell: Linking dietary nutrients to cellular metabolic regulation. World J Stem Cells 2025; In press

Received	2025-03-31 07:33
Peer-Review Started	2025-03-31 07:33
To Make the First Decision
Return for Revision	2025-04-23 11:47
Revised	2025-05-06 08:19
Second Decision	2025-07-03 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-03 07:23
Articles in Press	2025-07-03 07:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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