Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	107789
Country	Italy

Category	Surgery
Manuscript Type	Observational Study
Article Title	Exocrine pancreatic insufficiency and quality of life after oncologic gastric surgery: Evaluation from a single tertiary center
Manuscript Source	Unsolicited Manuscript
All Author List	Claudio Fiorillo, Sergio Alfieri, Beatrice Biffoni, Lodovica Langellotti, Chiara Lucinato, Giuseppe Massimiani, Roberta Menghi, Davide De Sio, Maria C Puzzangara, Fausto Rosa, Vanessa Gentili, Elisabetta Gambaro, Vincenzo Tondolo and Giuseppe Quero
Funding Agency and Grant Number
Corresponding Author	Beatrice Biffoni, MD, Digestive Surgery Unit, Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Largo Agostino Gemelli 8, Roma 00168, Italy. beatrice.biffoni@guest.policlinicogemelli.it
Key Words	Exocrine pancreatic insufficiency; Quality of life; Gastric surgery; Gastrectomy, Fecal elastase
Core Tip	Gastrectomy is a recognized cause of exocrine pancreatic insufficiency (EPI), yet its impact on quality of life (QoL) remains under-investigated. This study confirms gastrectomy as a significant contributor to EPI and identifies younger age, advanced stage, and aggressive histology as risk factors for more severe forms. Severe EPI is associated with a higher burden of gastrointestinal symptoms and leads to a notable deterioration in postoperative QoL.
Citation	Fiorillo C, Alfieri S, Biffoni B, Langellotti L, Lucinato C, Massimiani G, Menghi R, De Sio D, Puzzangara MC, Rosa F, Gentili V, Gambaro E, Tondolo V, Quero G. Exocrine pancreatic insufficiency and quality of life after oncologic gastric surgery: Evaluation from a single tertiary center. World J Gastrointest Surg 2025; In press

Received	2025-03-30 05:47
Peer-Review Started	2025-03-30 05:48
To Make the First Decision
Return for Revision	2025-04-09 09:49
Revised	2025-04-14 10:31
Second Decision	2025-07-18 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-18 07:35
Articles in Press	2025-07-18 07:35
Publication Fee Transferred	2025-06-11 16:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com