Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	107834
Country	Greece

Category	Oncology
Manuscript Type	Minireviews
Article Title	Clustered regularly interspaced short palindromic repeats and associated protein 9 gene editing in gastric cancer: Mechanisms, advances, and therapeutic potential
Manuscript Source	Invited Manuscript
All Author List	Grigorios Christodoulidis, Dimitra Bartzi, Kyriaki Tsagkidou, Alexandra Dimaki, Lydia Lazaridou, Kalliopi Vakalou, Konstantinos E Koumarelas and Dimitrios Schizas
Funding Agency and Grant Number
Corresponding Author	Grigorios Christodoulidis, MD, PhD, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Thessalia, Greece. gregsurg@yahoo.gr
Key Words	Gastric cancer; Gene-editing technologies; Clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeats-associated protein 9; Helicobacter pylori; Precision genome editing
Core Tip	Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 gene editing has emerged as a transformative tool in gastric cancer research, offering precise manipulation of oncogenes and tumor suppressor genes. This technology facilitates the dissection of gastric tumorigenesis mechanisms and the development of targeted therapies. Recent advancements highlight its potential in overcoming chemotherapy resistance and enhancing immunotherapeutic strategies. Despite challenges such as off-target effects and delivery mechanisms, ongoing research continues to refine CRISPR/CRISPR-associated protein 9 applications, underscoring its promise in improving outcomes for gastric cancer patients.
Citation	Christodoulidis G, Bartzi D, Tsagkidou K, Dimaki A, Lazaridou L, Vakalou K, Koumarelas KE, Schizas D. Clustered regularly interspaced short palindromic repeats and associated protein 9 gene editing in gastric cancer: Mechanisms, advances, and therapeutic potential. World J Gastrointest Pathophysiol 2025; In press

Received	2025-03-31 10:00
Peer-Review Started	2025-03-31 10:00
To Make the First Decision
Return for Revision	2025-04-08 08:58
Revised	2025-04-22 04:25
Second Decision	2025-06-16 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-16 10:44
Articles in Press	2025-06-16 10:44
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Edit the Manuscript by Language Editor
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ISSN	2150-5330 (online)
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