Publication Name	World Journal of Gastroenterology
Manuscript ID	107865
Country	China

Category	Cell Biology
Manuscript Type	Letter to the Editor
Article Title	From scRNA-seq to therapeutic targets: Unveiling the impact of activated mast cells on intestinal dysfunction in acute pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Bin Li
Funding Agency and Grant Number	Funding Agency Grant Number the Top-level Talents Support Program of Yangzhou University “Lv Yang Jin Feng” Outstanding Doctor of Yangzhou Natural Science Foundation of Jiangsu Province BK20240907
Corresponding Author	Bin Li, Full Professor, PhD, Institution of compared medicine, Yangzhou University, South Daxue Road 88, Yangzhou 225009, Jiangsu Province, China. lib111701@163.com
Key Words	Acute pancreatitis; Single-cell RNA sequencing; Mast cells; CCL5; Intestinal barrier
Core Tip	Applying advanced single-cell transcriptomics, Wei et al’s study elucidates the cellular heterogeneity of the intestine during early acute pancreatitis (AP) and identifies activated mast cells and their CCL5 secretion which are key contributors to gut barrier disruption. These findings provide novel insights into AP pathophysiology and highlight potential avenues for targeted therapeutic interventions. Moreover, the study underscores the value of integrative, multidimensional approaches in deciphering complex inflammatory responses.
Citation	Li B. From scRNA-seq to therapeutic targets: Unveiling the impact of activated mast cells on intestinal dysfunction in acute pancreatitis. World J Gastroenterol 2025; In press

Received	2025-04-08 16:35
Peer-Review Started	2025-04-08 16:35
To Make the First Decision
Return for Revision	2025-04-23 01:33
Revised	2025-04-28 03:35
Second Decision	2025-06-16 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-16 06:51
Articles in Press	2025-06-16 06:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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