Publication Name	World Journal of Clinical Oncology
Manuscript ID	107875
Country	Brazil

Category	Oncology
Manuscript Type	Review
Article Title	Circulating tumor DNA in biliary tract cancers: A review of current applications
Manuscript Source	Invited Manuscript
All Author List	Maria Fernanda Teixeira, Mitesh Borad and Pedro Luiz Serrano Uson Junior
Funding Agency and Grant Number
Corresponding Author	Pedro Luiz Serrano Uson Junior, Associate Professor, Full Professor, MD, Senior Research Fellow, Center for Personalized Medicine, Hospital Israelita Albert Einstein, Hospital Israelita Albert Einstein, 627/701 Av. Albert Einstein, Morumbi, Sao Paulo, CEP 05651-901, Brazil. pedroluiz_uson@hotmail.com., Sao Paulo 05651901, Brazil. pedroluiz_uson@hotmail.com
Key Words	Biliary tract cancer; Circulating tumor DNA; Genomic profiling; Bile-derived circulating tumor DNA; Clonal evolution; Mutation clearance
Core Tip	Molecular profiling of biliary tract cancers has significantly transformed the management of these diseases by paving the way for a broader range of therapeutic options, leading to improved survival outcomes. Given the scarcity of tissue, circulating tumor DNA (ctDNA) has emerged as a promising non-invasive biomarker for genomic profiling, with high concordance with genomic alterations identified in tissue, particularly in therapy-naïve and metastasis-derived samples. Furthermore, ctDNA has a strong prognostic association and is an effective strategy for monitoring patients during systemic treatment.
Citation	Teixeira MF, Borad M, Uson Junior PLS. Circulating tumor DNA in biliary tract cancers: A review of current applications. World J Clin Oncol 2025; In press

Received	2025-03-30 11:52
Peer-Review Started	2025-03-30 11:52
To Make the First Decision
Return for Revision	2025-05-17 07:30
Revised	2025-05-29 20:38
Second Decision	2025-09-04 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-04 08:44
Articles in Press	2025-09-04 08:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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